Dr. Mengyu Jia Profile

Dr. Mengyu Jia

Postdoc at Stanford Univ School of Medicine

SPIE Involvement:

Author

Publications (16)

SPIE Journal Paper | 1 January 2021 Open Access

Review of in vivo optical molecular imaging and sensing from x-ray excitation

Brian Pogue, Rongxiao Zhang, Xu Cao, Mengyu Jia, Arthur Petusseau, Petr Bruza, Sergei Vinogradov

JBO, Vol. 26, Issue 01, 010902, (January 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.1.010902

KEYWORDS: X-rays, Tissue optics, X-ray imaging, X-ray optics, Luminescence, In vivo imaging, Tissues, Molecular imaging, Signal detection, X-ray sources

Read Abstract +

Significance: Deep-tissue penetration by x-rays to induce optical responses of specific molecular reporters is a new way to sense and image features of tissue function in vivo. Advances in this field are emerging, as biocompatible probes are invented along with innovations in how to optimally utilize x-ray sources. Aim: A comprehensive review is provided of the many tools and techniques developed for x-ray-induced optical molecular sensing, covering topics ranging from foundations of x-ray fluorescence imaging and x-ray tomography to the adaptation of these methods for sensing and imaging in vivo. Approach: The ways in which x-rays can interact with molecules and lead to their optical luminescence are reviewed, including temporal methods based on gated acquisition and multipoint scanning for improved lateral or axial resolution. Results: While some known probes can generate light upon x-ray scintillation, there has been an emergent recognition that excitation of molecular probes by x-ray-induced Cherenkov light is also possible. Emission of Cherenkov radiation requires a threshold energy of x-rays in the high kV or MV range, but has the advantage of being able to excite a broad range of optical molecular probes. In comparison, most scintillating agents are more readily activated by lower keV x-ray energies but are composed of crystalline inorganic constituents, although some organic biocompatible agents have been designed as well. Methods to create high-resolution structured x-ray-optical images are now available, based upon unique scanning approaches and/or a priori knowledge of the scanned x-ray beam geometry. Further improvements in spatial resolution can be achieved by careful system design and algorithm optimization. Current applications of these hybrid x-ray-optical approaches include imaging of tissue oxygenation and pH as well as of certain fluorescent proteins. Conclusions: Discovery of x-ray-excited reporters combined with optimized x-ray scan sequences can improve imaging resolution and sensitivity.

DOWNLOAD PAPER

Proceedings Article | 28 May 2019 Paper

A deep learning approach for dual-energy CT imaging using a single-energy CT data

Wei Zhao, Tianling Lv, Peng Gao, Liyue Shen, Xianjin Dai, Kai Cheng, Mengyu Jia, Yang Chen, Lei Xing

Proceedings Volume 11072, 1107222 (2019) https://doi.org/10.1117/12.2534433

KEYWORDS: Computed tomography, Iodine, X-ray computed tomography, Dual energy imaging, Scanners, Denoising

Read Abstract +

Proceedings Article | 8 April 2019 Paper

Pharmacokinetic biodistribution assessment of Phosphorescent sensor, PtG4 Oxyphor in mice for optimization of in vivo oxygenation imaging

Mengyu Jia, Jennifer Shell, Xu Cao, Jason Gunn, Sergei Vinogradov, Brian Pogue

Proceedings Volume 10862, 108621H (2019) https://doi.org/10.1117/12.2513220

KEYWORDS: Cerenkov radiation imaging, In vivo imaging, Tumors, Luminescence, Medicine, Imaging systems

Read Abstract +

Proceedings Article | 7 March 2019 Presentation + Paper

Tomographic Cherenkov-excited luminescence scanned imaging based on back-projection reconstruction demonstrates 0.3mm spatial resolution for molecular reporter through 2-3cm of tissue

Mengyu Jia, Xu Cao, Jason Gunn, Petr Bruza, Shudong Jiang, Brian Pogue

Proceedings Volume 10862, 108621A (2019) https://doi.org/10.1117/12.2513231

KEYWORDS: Luminescence, X-rays, Tomography, Signal to noise ratio, Tissues, Radiotherapy, Photons, Image restoration, Spatial resolution, Computed tomography

Read Abstract +

Cherenkov-excited luminescence scanned imaging (CELSI) is achieved with External Beam Radiotherapy, to map out molecular luminescence intensity or lifetime in tissue. In order to realize a deeper imaging depth with a reasonable spatial resolution, we optimized the original scanning gesture to do in a similar way to computed tomography (CT) and the image reconstruction was instead used a customized Maximum-likelihood expectation maximization (ML-EM) for CELSI. In tomographic CELSI (TCELSI), tomographic images are generated by irradiating the subject using a sequence of programmed X-ray beams at a fixed projection angle, while sensitive measurement is to take a sum for all image pixels from an intensified charge-coupled device. By restricting the X-ray excitation to a single, narrow beam of radiation, the origin of the optical photons can be inferred regardless of where these photons were detected, and how many times they scattered in tissue. Measurement geometry was designed for clinical expectation: CT scanning was achieved by a clinical linear accelerator (LINAC), where X-ray beam sequence and multiple projections were realized with multi leaf collimator (MLC) and gantry movement, respectively. Furthermore, in most modern External Beam Radiotherapy, MLC movement is synchronized with gantry angle to release a uniform radiation, and some of treatment plans, e.g., Intensity Modulated Radiation Therapy (IMRT), have a potential to match the scanning way mentioned. By including Cherenkov imaging results, medium surface profile can be additionally acquired, which can be used as boundary reference to do depth correction and co-register with molecular images. Resolution phantom studies showed that a 0.3 mm diameter capillary tube containing 0.01 nM luminescent nanospheres could be recognized at a depth of 21 mm into tissue-like media. Small animal imaging with a 1 mm diameter cylindrical target demonstrated that fast 3D data acquisition was achieved by a multi-pinhole collimator to image local luminescence 20mm deep.

Proceedings Article | 4 March 2019 Presentation

Advancing optical methods for real-time non-contact pO2 estimation during external beam radiation therapy (Conference Presentation)

Ethan Philip LaRochelle, Jennifer Shell, Mengyu Jia, Xu Cao, Petr Bruza, Sergei Vinogradov, Brian Pogue

Proceedings Volume 10862, 108621E (2019) https://doi.org/10.1117/12.2511292

KEYWORDS: Radiotherapy, Beam analyzers, Tumors, Oxygen, Solids, Hypoxia, Tissue optics, In vivo imaging, Environmental sensing, Imaging devices

Read Abstract +

SPIE Journal Paper | 22 November 2018 Open Access

Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation

Xu Cao, Shudong Jiang, Mengyu Jeremy Jia, Jason Gunn, Tianshun Miao, Scott Davis, Petr Bruza, Brian Pogue

JBO, Vol. 24, Issue 05, 051405, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.5.051405

KEYWORDS: Short wave infrared radiation, Luminescence, Cameras, In vivo imaging, Infrared imaging, Infrared radiation, Electron beams, Tissues, Radiotherapy, Absorption

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 20 March 2018 Open Access

Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom

Syed Rakin Ahmed, Mengyu Jia, Petr Bruza, Sergei Vinogradov, Shudong Jiang, David Gladstone, Lesley Jarvis, Brian Pogue

JBO, Vol. 23, Issue 03, 030504, (March 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.3.030504

KEYWORDS: Luminescence, Tissue optics, Signal to noise ratio, Tissues, 3D image processing, Computed tomography, Phosphorescence, Lymphatic system, Skin, Signal detection

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 14 March 2018 Presentation

Structural Cherenkov luminescence imaging with Hadamard-patterned field illumination (Conference Presentation)

Mengyu Jia, Petr Bruza, Ethan Philip Larochelle, Jennifer Shel, Brian Pogue

Proceedings Volume 10478, 1047814 (2018) https://doi.org/10.1117/12.2292932

KEYWORDS: Luminescence, Structural imaging, Tomography, Compressed sensing, Medical physics, Tissues, Collimators, Image quality

Read Abstract +

SPIE Journal Paper | 5 May 2016 Open Access

Coupling between radiative transport and diffusion approximation for enhanced near-field photon-migration modeling based on transient photon kinetics

Mengyu Jia, Huijuan Zhao, Jiao Li, Lingling Liu, Limin Zhang, Jingying Jiang, Feng Gao

JBO, Vol. 21, Issue 05, 050501, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.5.050501

KEYWORDS: Diffusion, Near field, Optical properties, 3D modeling, Photon transport, Mathematical modeling, Collimation, Lithium, Biomedical optics, Physics

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 18 March 2016 Paper

A modified laminar optical tomography system with small dip-angle and the initial validation

Huijuan Zhao, Shuang Wang, Mengyu Jia, Xueying Chen, Jin Qi, Jing Tian, Wenjuan Ma, Jiao Li, Feng Gao

Proceedings Volume 9700, 97001B (2016) https://doi.org/10.1117/12.2213842

KEYWORDS: Optical tomography, Spatial resolution, Image restoration, Distortion, Monte Carlo methods, Algorithm development, Optical scanning systems, Optical testing, Detector development, Reconstruction algorithms, Mirrors, Image quality, Objectives

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

Parameterized source term in the diffusion approximation for enhanced near-field modeling of collimated light

Mengyu Jia, Shuang Wang, Xueying Chen, Feng Gao, Huijuan Zhao

Proceedings Volume 9706, 97061F (2016) https://doi.org/10.1117/12.2214722

KEYWORDS: Near field, Collimation, Optical properties, Mathematical modeling, Scattering, Diffusion, Diffuse reflectance spectroscopy, Monte Carlo methods, Absorption, Tissue optics

Read Abstract +

Proceedings Article | 10 March 2015 Paper

Improvement of the background optical property reconstruction of the two-layered slab sample based on a region-stepwise-reconstruction method

Ming Liu, Zhuanping Qin, Mengyu Jia, Huijuan Zhao, Feng Gao

Proceedings Volume 9305, 93051X (2015) https://doi.org/10.1117/12.2077371

KEYWORDS: Optical properties, Brain, Biomedical optics, Head, Diffuse optical tomography, Neuroimaging, Absorption, Ions, Brain imaging, Numerical simulations

Read Abstract +

Proceedings Article | 26 February 2015 Paper

An opto-electronic joint detection system based on DSP aiming at early cervical cancer screening

Weiya Wang, Mengyu Jia, Feng Gao, Lihong Yang, Pengpeng Qu, Changping Zou, Pengxi Liu, Huijuan Zhao

Proceedings Volume 9303, 93032W (2015) https://doi.org/10.1117/12.2076587

KEYWORDS: Tissue optics, Tissues, Cervical cancer, Digital signal processing, Optoelectronics, Reflectivity, Light emitting diodes, Gold, Signal attenuation, Databases

Read Abstract +

Proceedings Article | 17 September 2014 Paper

A fast 3D image reconstruction method based on Monte-Carlo simulation for laminar optical tomography

Mengyu Jia, Shanshan Cui, Xueying Chen, Huijuan Zhao, Feng Gao

Proceedings Volume 9230, 923016 (2014) https://doi.org/10.1117/12.2070206

KEYWORDS: Reconstruction algorithms, Image restoration, Monte Carlo methods, Optical tomography, Absorption, 3D image reconstruction, Algorithm development, Detection and tracking algorithms, Sensors, Mirrors

Read Abstract +

Proceedings Article | 4 March 2014 Paper

A laminar optical tomography system for the early cervical cancer diagnosis

Shanshan Cui, Mengyu Jia, Xueying Chen, Wei Meng, Feng Gao, Huijuan Zhao

Proceedings Volume 8952, 895217 (2014) https://doi.org/10.1117/12.2036527

KEYWORDS: Distortion, Objectives, Cervical cancer, Monte Carlo methods, Optical tomography, Image quality, Monochromatic aberrations, Mirrors, Sensors, Neodymium

Read Abstract +

Proceedings Article | 25 March 2013 Paper

The ellipsoid parametric description for the shape-based image reconstruction algorithm of diffuse optical tomography

Yuan Wang, Linhui Wu, Mengyu Jia, Lingling Liu, Huijuan Zhao, Feng Gao

Proceedings Volume 8578, 85782R (2013) https://doi.org/10.1117/12.2000813

KEYWORDS: Optical properties, Reconstruction algorithms, Image restoration, Tissues, Diffuse optical tomography, Signal to noise ratio, Biomedical optics, Data modeling, Tumors, Inverse problems

Read Abstract +

Showing 5 of 16 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years