Mr. Onur Cetinkaya Profile

Onur Cetinkaya

at Institute of Physical Chemistry PAS

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Author

Publications (7)

SPIE Journal Paper | 8 October 2024 Open Access

In vivo volumetric analysis of retinal vascular hemodynamics in mice with spatio-temporal optical coherence tomography

Piotr Węgrzyn, Wiktor Kulesza, Maciej Wielgo, Sławomir Tomczewski, Anna Galińska, Bartłomiej Bałamut, Katarzyna Kordecka, Onur Cetinkaya, Andrzej Foik, Robert Zawadzki, Dawid Borycki, Maciej Wojtkowski, Andrea Curatolo

NPh, Vol. 11, Issue 04, 045003, (October 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.4.045003

KEYWORDS: Eye, Hemodynamics, Retina, Imaging systems, In vivo imaging, Cameras, Optical coherence tomography, Signal to noise ratio, Neurophotonics, Tunable filters

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SignificanceMicrocirculation and neurovascular coupling are important parameters to study in neurological and neuro-ophthalmic conditions. As the retina shares many similarities with the cerebral cortex and is optically accessible, a special focus is directed to assessing the chorioretinal structure, microvasculature, and hemodynamics of mice, a vital animal model for vision and neuroscience research.AimWe aim to introduce an optical imaging tool enabling in vivo volumetric mouse retinal monitoring of vascular hemodynamics with high temporal resolution.ApproachWe translated the spatio-temporal optical coherence tomography (STOC-T) technique into the field of small animal imaging by designing a new optical system that could compensate for the mouse eye refractive error. We also developed post-processing algorithms, notably for the assessment of (i) localized hemodynamics from the analysis of pulse wave–induced Doppler artifact modulation and (ii) retinal tissue displacement from phase-sensitive measurements.ResultsWe acquired high-quality, in vivo volumetric mouse retina images at a rate of 113 Hz over a lateral field of view of ∼500 μm. We presented high-resolution en face images of the retinal and choroidal structure and microvasculature from various layers, after digital aberration correction. We were able to measure the pulse wave velocity in capillaries of the outer plexiform layer with a mean speed of 0.35 mm/s and identified venous and arterial pulsation frequency and phase delay. We quantified the modulation amplitudes of tissue displacement near major vessels (with peaks of 150 nm), potentially carrying information about the biomechanical properties of the retinal layers involved. Last, we identified the delays between retinal displacements due to the passing of venous and arterial pulse waves.ConclusionsThe developed STOC-T system provides insights into the hemodynamics of the mouse retina and choroid that could be beneficial in the study of neurovascular coupling and vasculature and flow speed anomalies in neurological and neuro-ophthalmic conditions.

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Proceedings Article | 11 August 2023 Paper

Ultrafast volumetric imaging with a spatio-temporal optical coherence tomography (STOC-T) system for monitoring hemodynamics in mouse retinal vessels directly from structural data

Wiktor Kulesza, Maciej Wielgo, Piotr Węgrzyn, Sławomir Tomczewski, Onur Cetinkaya, Katarzyna Kordecka, Anna Galińska, Bartłomiej Bałamut, Egidijus Auksorius, Andrzej Foik, Robert Zawadzki, Maciej Wojtkowski, Dawid Borycki, Andrea Curatolo

Proceedings Volume 12632, 126320O (2023) https://doi.org/10.1117/12.2670568

KEYWORDS: Imaging systems, Hemodynamics, Optical coherence tomography, Ultrafast imaging, Eye, Retina, Optical sensing, Crosstalk, Cameras, Ultrafast phenomena

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Proceedings Article | 27 March 2023 Poster

Spatio-temporal optical coherence tomography (STOC-T) focal plane adjustment in the mouse retina aided by a fundus camera

Wiktor Kulesza, Kamil Łuczkiewicz, Piotr Węgrzyn, Sławomir Tomczewski, Dawid Borycki, Piotr Ciąćka, Onur Cetinkaya, Maciej Wielgo, Katarzyna Kordecka, Anna Galińska, Egidijus Auksorius, Andrzej Foik, Robert Zawadzki, Maciej Wojtkowski, Andrea Curatolo

Proceedings Volume PC12367, PC123671T (2023) https://doi.org/10.1117/12.2652956

KEYWORDS: Retina, Cameras, Optical coherence tomography, Eye, Tissues, Optical alignment, Near infrared, Imaging systems, Calibration

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Proceedings Article | 27 March 2023 Poster

Long-range frequency-domain optical delay line based on a spinning tilted mirror for low-cost ocular biometry

Maria Pilar Urizar, Alberto de Castro, Enrique Gambra, Álvaro de la Peña, Onur Cetinkaya, Susana Marcos, Andrea Curatolo

Proceedings Volume PC12367, PC123671S (2023) https://doi.org/10.1117/12.2652952

KEYWORDS: Mirrors, Optical coherence tomography, Integrated optics, Distance measurement, Surgery, Retina, Prototyping, Optical simulations, Manufacturing, Eye models

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Proceedings Article | 17 March 2023 Presentation

High-speed, in vivo, volumetric imaging of mouse retinal tissue with spatio-temporal optical coherence tomography (STOC-T)

Piotr Wegrzyn, Sławomir Tomczewski, Dawid Borycki, Wiktor Kulesza, Maciej Wielgo, Katarzyna Kordecka, Anna Galińska, Onur Cetinkaya, Piotr Ciąćka, Egidijus Auksorius, Andrzej Foik, Robert Zawadzki, Maciej Wojtkowski, Andrea Curatolo

Proceedings Volume PC12360, PC123600U (2023) https://doi.org/10.1117/12.2648893

KEYWORDS: Optical coherence tomography, In vivo imaging, Eye, Retinal scanning, Cameras, Tissue optics, Retina, Optical alignment, Interfaces, Collimation

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Proceedings Article | 7 March 2022 Presentation

Air puff-coupled multi-spot OCT for assessment of asymmetries in corneal biomechanics

Karol Karnowski, Jadwiga Milkiewicz, Angela Pachacz, Andrea Curatolo, Onur Cetinkaya, Rafal Pietruch, Piotr Ciacka, Ashkan Eliasy, Ahmed Abass, Ahmed Elsheikh, Susana Marcos, Maciej Wojtkowski

Proceedings Volume PC11941, PC119410U (2022) https://doi.org/10.1117/12.2609511

KEYWORDS: Optical coherence tomography, Eye models, Cones, Finite element methods, Pathology, In vivo imaging, Eye, Cameras

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Proceedings Article | 5 March 2021 Presentation

Corrections of axial shift artifact in dynamic swept-source optical coherence tomography

Karol Karnowski, Jedrzej Solarski, Andrea Curatolo, Angela Pachacz, Onur Cetinkaya, Alejandra Consejo, Susana Marcos, Maciej Wojtkowski

Proceedings Volume 11630, 116301O (2021) https://doi.org/10.1117/12.2578928

KEYWORDS: Optical coherence tomography, Phase interferometry, Motion measurement, Interferometry, Algorithm development, Optical simulations, Image quality, Cornea

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Showing 5 of 7 publications

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