Dr. Pierre O. Bagnaninchi Profile

Dr. Pierre O. Bagnaninchi

Group leader at Centre Regenerative Medicine

SPIE Involvement:

Author

Publications (28)

Proceedings Article | 20 May 2022 Poster + Presentation + Paper

Evaluation of a dual-modal tissue imaging framework based on information fusion using optical coherence and bioimpedance tomography

Zhe Liu, Yunjie Yang, Pierre Bagnaninchi

Proceedings Volume 12136, 1213615 (2022) https://doi.org/10.1117/12.2621609

KEYWORDS: Optical coherence tomography, 3D image processing, Tissues, Sensors, Image restoration, Image processing, Reconstruction algorithms, Tomography, Tissue optics, Signal attenuation

Read Abstract +

Proceedings Article | 21 February 2019 Paper

Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography

Jonathan Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre Bagnaninchi

Proceedings Volume 10880, 108801K (2019) https://doi.org/10.1117/12.2508326

KEYWORDS: Denoising, Elastography, Motion estimation, Coherence (optics), Optical coherence tomography, Image enhancement, Statistical analysis, Image quality, Image resolution, Image analysis

Read Abstract +

Proceedings Article | 21 February 2019 Presentation + Paper

Real-time and non-invasive quantitative phase imaging of pancreatic ductal adenocarcinoma cell mechanical properties

D. Gillies, W. Gamal, M. Canel, Y. Reinwald, Y. Yang, A. J. El Haj, A. Serrels, P. Bagnaninchi

Proceedings Volume 10880, 108800H (2019) https://doi.org/10.1117/12.2508436

KEYWORDS: Digital holography, Phase imaging, Microscopy, Cancer, Cell mechanics, Stem cells, Elastography

Read Abstract +

Proceedings Article | 21 February 2019 Paper

Model-based iterative reconstruction for spectral-domain optical coherence tomography

Jonathan Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre Bagnaninchi

Proceedings Volume 10883, 108830O (2019) https://doi.org/10.1117/12.2509424

KEYWORDS: Optical coherence tomography, Model-based design, Reconstruction algorithms, Systems modeling, Spectroscopy, Fourier transforms, Tissues, Visualization, Medicine, Statistical modeling

Read Abstract +

Proceedings Article | 21 February 2017 Presentation + Paper

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy

D. Gillies, W. Gamal, A. Downes, Y. Reinwald, Y. Yang, A. El Haj, P. Bagnaninchi

Proceedings Volume 10067, 100670Y (2017) https://doi.org/10.1117/12.2251492

KEYWORDS: Tissue optics, Coherence (optics), Optical microscopy, Microscopy, Microfluidics, Phase measurement, Elastography, Tissue engineering, Environmental monitoring, Stem cells, Data modeling, Optical coherence tomography, Water

Read Abstract +

Proceedings Article | 9 March 2016 Paper

Online monitoring of mechanical properties of three-dimensional tissue engineered constructs for quality assessment

Yvonne Reinwald, Pierre Bagnaninchi, Ying Yang, Yanny Baba Ismail, Alicia El Haj

Proceedings Volume 9710, 971007 (2016) https://doi.org/10.1117/12.2212320

KEYWORDS: Elastography, Tissues, Tissue optics, Coherence (optics), 3D image processing, Tissue engineering, In vivo imaging, Manufacturing, Optical coherence tomography, Interfaces, Solids, Prototyping

Read Abstract +

Proceedings Article | 5 March 2015 Paper

Towards non-invasive 3D hepatotoxicity assays with optical coherence phase microscopy

Leonard Nelson, Andreas Koulovasilopoulos, Philipp Treskes, Peter Hayes, John Plevris, Pierre Bagnaninchi

Proceedings Volume 9322, 93220H (2015) https://doi.org/10.1117/12.2077997

KEYWORDS: Optical coherence tomography, 3D modeling, Coherence (optics), Tissue optics, Tissues, 3D image processing, Toxicity, Tomography, Optical microscopy, Microscopy

Read Abstract +

Proceedings Article | 1 March 2013 Paper

Monitoring cells in engineered tissues with optical coherence phase microscopy: Optical phase fluctuations as endogenous sources of contrast

P. Bagnaninchi, Christina Holmes, Maryam Tabrizian

Proceedings Volume 8580, 85800E (2013) https://doi.org/10.1117/12.2003730

KEYWORDS: Tissues, Doppler effect, Tissue optics, Coherence (optics), Optical coherence tomography, Optical microscopy, Microscopy, Microscopes, Biomedical optics, Live cell imaging

Read Abstract +

SPIE Journal Paper | 18 January 2013 Open Access

Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

Ying Yang, Asha Rupani, Pierre Bagnaninchi, Ian Wimpenny, Alan Weightman

JBO, Vol. 18, Issue 01, 019801, (January 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.1.019801

KEYWORDS: Optical properties, Polarization, Optical coherence tomography, Biomedical optics, Medicine, Regenerative medicine

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 November 2012 Open Access

Label-free assessment of adipose-derived stem cell differentiation using coherent anti-Stokes Raman scattering and multiphoton microscopy

Rabah Mouras, Pierre Bagnaninchi, Andrew Downes, Alistair Elfick

JBO, Vol. 17, Issue 11, 116011, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.116011

KEYWORDS: Second-harmonic generation, Collagen, Stem cells, Microscopy, Multiphoton microscopy, CARS tomography, Luminescence, In vitro testing, Signal processing, Bandpass filters

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 2 August 2012 Open Access

Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

Ying Yang, Asha Rupani, Ian Wimpenny, Alan Weightman, Pierre Bagnaninchi

JBO, Vol. 17, Issue 8, 081417, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081417

KEYWORDS: Collagen, Polarization, Birefringence, Optical fibers, Microscopy, Optical properties, Optical coherence tomography, Molecules, Visualization, Tissues

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 August 2011 Open Access

Two-dimensional and three-dimensional viability measurements of adult stem cells with optical coherence phase microscopy

Pierre Bagnaninchi, Nicola Drummond, Christina Holmes, Jamal Daoud, Maryam Tabrizian

JBO, Vol. 16, Issue 08, 086003, (August 2011) https://doi.org/10.1117/12.10.1117/1.3606561

KEYWORDS: Coherence (optics), Phase measurement, Microscopy, Stem cells, Signal to noise ratio, Optical microscopy, Biomedical optics, Optical coherence tomography, 3D image processing, 3D acquisition

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 9 June 2011 Paper

Nonlinear optical microscopy of adipose-derived stem cells induced towards osteoblasts and adipocytes

R. Mouras, P. Bagnaninchi, A. Downes, M. Muratore, A. Elfick

Proceedings Volume 8086, 80860Q (2011) https://doi.org/10.1117/12.889780

KEYWORDS: Stem cells, Microscopy, Second-harmonic generation, Image transmission, Multiphoton microscopy, CARS tomography, Collagen, Raman spectroscopy, Microscopes, Tissues

Read Abstract +

Proceedings Article | 11 February 2011 Paper

Measurements of adipose derived stem cell vitality with optical coherence phase microscopy

P. O. Bagnaninchi, C. Holmes, N. Drummond, J. Daoud, M. Tabrizian

Proceedings Volume 7898, 78980Y (2011) https://doi.org/10.1117/12.878601

KEYWORDS: Coherence (optics), Microscopy, Optical microscopy, Stem cells, Phase measurement, 3D image processing, Microscopes, Optical coherence tomography, Spectroscopy, Signal to noise ratio

Read Abstract +

Proceedings Article | 8 February 2011 Paper

The study of optical properties and proteoglycan content of tendons by PS-OCT

Ying Yang, Asha Rupani, Alan Weightman, Ian Wimpenny, Pierre Bagnaninchi, Mark Ahearne

Proceedings Volume 7898, 789808 (2011) https://doi.org/10.1117/12.877113

KEYWORDS: Collagen, Polarization, Birefringence, Optical fibers, Microscopy, Tissues, Optical properties, Optical coherence tomography, Microscopes, Molecules

Read Abstract +

Tendons are load-bearing collagenous tissues consisting mainly of type I collagen and various proteoglycans (PGs) including decorin and versican. It is widely accepted that highly orientated collagen fibers in tendons a play critical role for transferring tensile stress and demonstrate birefringent optical properties. However, the influence that proteoglycans have on the optical properties of tendons is yet to be fully elucidated. Tendinopathy (defined as a syndrome of tendon pain, tenderness and swelling that affects the normal function of the tissue) is a common disease associated with sporting injuries or degeneration. PG's are the essential components of the tendon extracellular matrix; changes in their quantities and compositions have been associated with tendinopathy. In this study, polarization sensitive optical coherence tomography (PS-OCT) has been used to reveal the relationship between proteoglycan content/location and birefringent properties of tendons. Tendons dissected from freshly slaughtered chickens were imaged at regular intervals by PS-OCT and polarizing light microscope during the extraction of PGs or glycosaminoglycans using established protocols (guanidine hydrochloride (GuHCl) or proteinase K solution). The macroscopic and microscopic time lapsed images are complimentary; mutually demonstrating that there was a higher concentration of PG's in the outer sheath region than in the fascicles; and the integrity of the sheath affected extraction process and the OCT birefringence bands. Extraction of PGs using GuHCl disturbed the organization of local collagen bundles, which corresponded to a reduction in the frequency of birefringence bands and the band width by PS-OCT. The feature of OCT penetration depth helped us to define the heterogeneous distribution of PG's in tendon, which was complimented by polarizing light microscopy. The results provide new insight of tendon structure and also demonstrate a great potential for using PS-OCT as a diagnostic tool to examine tendon pathology.

Proceedings Article | 11 February 2010 Paper

Monitoring adipose-derived stem cells within 3D carrier by combined dielectric spectroscopy and spectral domain optical coherence topography

P. Bagnaninchi

Proceedings Volume 7566, 756602 (2010) https://doi.org/10.1117/12.847013

KEYWORDS: Dielectrics, Optical coherence tomography, Dielectric spectroscopy, 3D image processing, Tissue optics, 3D metrology, Stem cells, Tissue engineering, Coherence (optics), Regenerative medicine

Read Abstract +

Proceedings Article | 11 February 2010 Paper

Combined optical coherence phase microscopy and impedance sensing measurements of differentiating adipose derived stem cells

P. Bagnaninchi

Proceedings Volume 7566, 756604 (2010) https://doi.org/10.1117/12.842257

KEYWORDS: Stem cells, Electrodes, Coherence (optics), Microscopes, Dielectrics, Gold, Microscopy, Optical microscopy, Optical coherence tomography, Image resolution

Read Abstract +

SPIE Journal Paper | 1 May 2009 Open Access

Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds

Yali Jia, Pierre-Olivier Bagnaninchi, Ying Yang, Alicia El Haj, Monica Hinds, Sean Kirkpatrick, Ruikang Wang

JBO, Vol. 14, Issue 03, 034014, (May 2009) https://doi.org/10.1117/12.10.1117/1.3130345

KEYWORDS: Optical coherence tomography, Microfluidics, Microfluidic imaging, Coherence imaging, Doppler tomography, Tissues, 3D image processing, Optical imaging, Tissue engineering, 3D modeling

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 24 February 2009 Paper

Elastin peptides increase lung cancer cell growth in 3D models

Jacek Pijanka, Ying Yang, Pierre Bagnaninchi, Laurent Debelle, Ganesh Sockalingum, Josep Sulé-Suso

Proceedings Volume 7179, 717907 (2009) https://doi.org/10.1117/12.813743

KEYWORDS: 3D modeling, Lung cancer, Cancer, Tumor growth modeling, Collagen, Optical coherence tomography, Lung, Tissues, Systems modeling, Biomedical optics

Read Abstract +

Proceedings Article | 20 February 2008 Paper

Optical properties of human tendons characterized by PSOCT and their relation to tendinopathy: a clinical study

P. Bagnaninchi, D. Churmakov, M. Bonesi, Y. Yang, C. Phelan, N. Maffulli, I. Meglinski, A. El Haj

Proceedings Volume 6854, 68541C (2008) https://doi.org/10.1117/12.763156

KEYWORDS: Polarization, Scattering, Birefringence, Tissues, Optical coherence tomography, Optical properties, Beam splitters, Tissue optics, Polarizers, Sensors

Read Abstract +

Proceedings Article | 11 February 2008 Paper

Application of polarization OCT in tissue engineering

Ying Yang, Mark Ahearne, Pierre Bagnaninchi, Bin Hu, Karen Hampson, Alicia El Haj

Proceedings Volume 6858, 68580K (2008) https://doi.org/10.1117/12.762958

KEYWORDS: Tissues, Optical coherence tomography, Collagen, Tissue engineering, Birefringence, Polarization, Nondestructive evaluation, Tissue optics, Superluminescent diodes, Microscopes

Read Abstract +

Proceedings Article | 6 February 2008 Paper

In situ monitoring of localized shear stress and fluid flow within developing tissue constructs by Doppler optical coherence tomography

Yali Jia, Pierre Bagnaninchi, Ruikang Wang

Proceedings Volume 6858, 68580G (2008) https://doi.org/10.1117/12.764720

KEYWORDS: Tissues, Optical coherence tomography, Microfluidics, Tissue optics, Doppler tomography, Scattering, Fluid dynamics, Imaging systems, Tissue engineering, 3D image processing

Read Abstract +

Proceedings Article | 8 February 2007 Paper

Characterization of local fluid flow in 3D porous construct characterized by Fourier domain Doppler optical coherence tomography

P. Bagnaninchi, Y. Yang, A. El Haj, M. Hinds, R. Wang

Proceedings Volume 6439, 64390H (2007) https://doi.org/10.1117/12.701083

KEYWORDS: Microfluidics, Tissues, Optical coherence tomography, Tissue engineering, Doppler tomography, Microfluidic imaging, Tissue optics, Fluid dynamics, Scattering, 3D image processing

Read Abstract +

Proceedings Article | 8 February 2007 Paper

Characterization of scaffold architecture by optical coherence tomography

Ying Yang, Pierre Bagnaninchi, Cassilda Cunha-Reis, Halil Aydin, Erhan Piskin, Alicia El Haj

Proceedings Volume 6439, 64390G (2007) https://doi.org/10.1117/12.701103

KEYWORDS: Optical coherence tomography, Tissues, Polymers, Tissue engineering, Manufacturing, Fabrication, Confocal microscopy, Crystals, Microscopy, Nondestructive evaluation

Read Abstract +

Proceedings Article | 7 February 2007 Paper

A novel OCT-based micro-indentation technique for mechanical characterization of soft tissues

Ying Yang, Pierre Bagnaninchi, Mark Ahearne, Ruikang Wang, Kuo-Kang Liu

Proceedings Volume 6439, 643907 (2007) https://doi.org/10.1117/12.700819

KEYWORDS: Tissues, Optical coherence tomography, Nondestructive evaluation, Spherical lenses, Image resolution, Coherence imaging, Solids, Optical resolution, Optical imaging, Light sources

Read Abstract +

Proceedings Article | 7 February 2007 Paper

Continuous monitoring of tissue growth inside a perfusion bioreactor by optical coherence tomography

P. Bagnaninchi, A. El Haj, Y. Yang

Proceedings Volume 6439, 643903 (2007) https://doi.org/10.1117/12.701052

KEYWORDS: Tissues, Optical coherence tomography, Tissue engineering, Scattering, Tissue optics, In vitro testing, Microfluidics, Superluminescent diodes, Nondestructive evaluation, Collagen

Read Abstract +

Proceedings Article | 1 March 2006 Paper

Monitoring tissue formation and organization of engineered tendon by optical coherence tomography

P. Bagnaninchi, Y. Yang, N. Maffulli, R. Wang, A. El Haj

Proceedings Volume 6084, 608419 (2006) https://doi.org/10.1117/12.646186

KEYWORDS: Optical coherence tomography, Tissues, Tissue engineering, Collagen, Confocal microscopy, Tissue optics, Traumatic brain injury, Nondestructive evaluation, Optical engineering, Structured optical fibers

Read Abstract +

Proceedings Article | 15 April 2005 Paper

Monitoring cell profile in tissue engineered constructs by OCT

Ying Yang, Pierre Bagnaninchi, Mairead Wood, Alicia El Haj, Elvire Guyot, Arnaud Dubois, Ruikang Wang

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.592752

KEYWORDS: Optical coherence tomography, Tissues, Tissue engineering, Tissue optics, Bone, Polymers, Nondestructive evaluation, Proteins, Biological research, Magnetic resonance imaging

Read Abstract +