Prof. Ross W. Boyle Profile

Prof. Ross W. Boyle

at Univ of Hull

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Proceedings Article | 7 August 2019 Paper

A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy

Susan Callaghan, Mikhail Filatov, Huguette Savoie, Ross Boyle, Mathias Senge

Proceedings Volume 11070, 110709I (2019) https://doi.org/10.1117/12.2525246

KEYWORDS: Photodynamic therapy, In vitro testing, Chemistry

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Over the past four years we have developed BODIPY dyads capable of triplet state generation from charge transfer states generated by photoinduced electron transfer. In the current work we identify a lead compound for application in photodynamic therapy. This system is composed of a phenylanthracene electron donor unit and a dimethyl-substituted BODIPY acceptor unit. We have demonstrated that this compound, in sub-micromolar concentrations, can effectively generate singlet oxygen in polar solvents and induce cytotoxicity in human breast cancer cells (MDA-MB-468) when exposed to light. The photophysical properties of these compounds are chemically tunable and thus open the door not only to a new class of photodynamic therapy photosensitizers, but also agents for triplet-triplet annihilation up-conversion applications.

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