Dr. Shinjiro Fukami Profile

Dr. Shinjiro Fukami

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Proceedings Article | 20 February 2020 Paper

Salted cadaver brain measurement for light attenuation of PDT

Emiyu Ogawa, Jiro Akimoto, Shinjiro Fukami, Tsunenori Arai, Hiroshi Kumagai

Proceedings Volume 11238, 112381I (2020) https://doi.org/10.1117/12.2551473

KEYWORDS: Brain, Signal attenuation, Photodynamic therapy, Tissue optics, Tissues, Optical testing, In situ metrology, Endoscopes, Sodium, Optical properties

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We investigated light attenuation in a salted cadaver brain at 664 nm, which is the excitation wavelength of photodynamic therapy using Talaporfin sodium. Technology for diagnosis or treatment using light such as photodiagnosis and photodynamic therapy has been spread recently. Especially the therapeutic lesion by photodynamic therapy is dominated by the light distribution in the tissue under the case of uniform photosensitizer distribution. Estimation of therapeutic lesions is important to ensure the effectiveness and safety of brain tumor photodynamic therapy since important parts that should not be damaged are adjacent. Previously reported optical properties of the human brain in the literature vary widely, since the preparation and measurement methods are different. In this study, we measured the light attenuation in a salted cadaver brain using a practical method. In the employed salted cadaver brain, the mechanical and optical properties could be maintained as close as possible to those under operative conditions in living patients. Until the cerebral ventricle was reached, a neuroendoscope was inserted into the brain. A thin diffuse irradiation probe of 10 mm in irradiation length was inserted using the endoscope and advanced 10 mm from the endoscope tip. An optical fiber for measurement was inserted by another path from the brain surface. Optical fiber was put into a puncture needle, and a pair of needles was used to puncture the tissue and reach the same cerebral ventricle in which the endoscope tip and diffuse irradiation probe were positioned. Attenuation at 664 nm in salted cadaver brain in situ was reasonably measured by the withdrawal technique and we think this method might be appropriate for the measurement of inhomogeneous biological tissues.

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