The ultrahigh laser intensities enabled by high power lasers facilitate the generation of high energy ions using accelerating gradients many million times that of conventional accelerators. The maturation of these sources relies on breakthroughs in the generated beam parameters and improved reproducibility and repetition rate. We used two independent state-of-the-art femtosecond laser systems capable of repetitive operation to accelerate protons and carbons to high energies (>50 MeV and 30 MeV/nucleon respectively) in the relativistically induced transparency (RIT) regime. We demonstrate that acceleration is optimised for different laser prepulse levels by varying the initial target thickness, relaxing laser requirements for energetic ion generation. We elucidated the acceleration dynamics with cutting-edge 3D simulation, showing a) the role of the laser prepulse in pre-expanding the target, and b) radiation pressure assisted electron expulsion from the target during relativistically induced transparency, generating a strong space charge field which rapidly accelerates ions. Our demonstration of a robust acceleration mechanism that does not require complicated targetry nor a single-shot prepulse suppressing plasma mirror is an important step forward for developing high repetition rate applications of laser driven ion sources.
Karl Zeil, Stefan Assenbaum, Constantin Bernert, Florian Brack, Thomas Kluge, Florian Kroll, Josefine Metzkes-Ng, Martin Rehwald, Marvin Umlandt, Milenko Vescovi, Tim Ziegler, Ulrich Schramm
Ion acceleration by compact laser-plasma sources promises a variety of applications, but reaching the required beam quality parameters demands a high level of understanding and control over the laser-plasma interaction process. Several advanced acceleration schemes, including the Relativistically Induced Transparency (RIT) regime, have been proposed and investigated in search of a stable acceleration regime for proton energies beyond 100 MeV.
Central component in the RIT scheme is the absorption of the electromagnetic laser field by the target and the generated plasma respectively. In joint studies, we experimentally explore these interactions at the onset of transparency at the two laser systems DRACO PW (HZDR) and J-KAREN (KPSI). With our transmission diagnostics, we characterize this onset with respect to the laser temporal profile in order to learn about the sensitivity of laser input parameters to increase the process’s robustness. Using ultra-short, high and low-contrast laser pulses on thin solid density foil targets, we observe high performance proton beams in an expanded foil case. The results of spectral, spatial, and energy analysis of the effects on the transmission and its correlation with the acceleration performance indicate changes in the plasma interaction itself.
We report on the time-resolved observation of transient laser-induced breakdown (LIB) during the leading edge of high-intensity petawatt-class laser pulses with peak intensities up to 6x10^21 W/cm^2 in interaction with dielectric cryogenic hydrogen jet targets. The results show that LIB occurs much earlier than what is typically expected following the concept of barrier suppression ionization and that the laser pulse duration dependence of LIB and laser-induced damage threshold (LIDT) is very relevant to high-intensity laser-solid interactions. We demonstrate an effective approach to determine the onset of LIB, i.e. the starting point of target pre-expansion, by comparing a laser contrast measurement with a characterization study of the target specific LIB thresholds.
Florian-Emanuel Brack, Florian Kroll, Elke Beyreuther, Stephan Kraft, Josefine Metzkes-Ng, Jörg Pawelke, Marvin Reimold, Ulrich Schramm, Marvin Elias Paul Umlandt, Tim Ziegler, Karl Zeil
KEYWORDS: Tumors, In vivo imaging, Laser irradiation, Animal model studies, Tumor growth modeling, Reliability, Mouse models, Laser radiation, High power lasers, Dosimetry
Recent oncological studies identified beneficial properties of radiation applied at ultra-high dose rates several orders of magnitude higher than the clinical standard of ~1 Gy/min. At the high-power laser source Draco, operated at Helmholtz-Zentrum Dresden-Rossendorf, a complete laser-driven proton research platform for diverse user-specific small animal models was demonstrated. Tunable single-shot doses up to around 20 Gy to millimeter-scale volumes on nanosecond time scales, equivalent to instantaneous dose rates of around 10^9 Gy/s. Spatially homogenized dose distributions tailored to the sample can be delivered with polychromatic proton beams of energies greater than 60 MeV, which have been provided with unprecedented stability and long-term reliability.
These achievements allowed to successfully conduct the first radiobiological in vivo study using a laser-driven proton source. The pilot irradiation study was performed on human tumors in a mouse model, showing the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source.
The laser-based proton irradiation platform at the Draco PW facility enables systematic radiobiological studies within an unprecedented range of beam parameters and demonstrate a solution for minimally invasive volumetric dosimetry at ultra-high dose rates.
Florian-Emanuel Brack, Florian Kroll, Lennart Gaus, Constantin Bernert, Elke Beyreuther, Thomas Cowan, Leonhard Karsch, Stephan Kraft, Elisabeth Lessmann, Josefine Metzkes-Ng, Jörg Pawelke, Martin Rehwald, Marvin Reimold, Hans-Peter Schlenvoigt, Ulrich Schramm, Manfred Sobiella, Marvin Umlandt, Tim Ziegler, Karl Zeil
Laser-driven proton pulse provide unique properties in terms of pulse structure (ns) and instantaneous dose rate (10^9 Gy/s) but - inherently broadband and highly divergent - pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for three-dimensional cases. We present the successful implementation and characterisation of a highly efficient and tuneable dual pulsed solenoid beamline at the Draco PW facility[1] to generate volumetric dose distribution tailored to specific applications[2].
The vast experimental scope and already successfully performed studies range from systematic volumetric in-vivo tumour irradiations in a dedicated mouse model (with a stable mean dose delivery of ±10 % and a spatial dose homogeneity of ±5 % over a cylindrical volume of 5 mm diameter and height) to high-dose-rate irradiations in the FLASH regime (using proton peak dose rates of up to 10^9 Gy/s with about 20 Gy/shot homogeneously over a cylindrical sample volume of 4.5 mm diameter and 3 mm height) as well as particle diagnostics commissioning (with a multitude of spatial and spectral dose distributions).
The beamline setup is complemented by a complex beam monitoring and dosimetry detector suite adapted to the ultra-high dose rate pulses and is in its unique synergy and redundancy capable of %-level precision dose delivery to samples as required for systematic irradiation studies. In addition to established radiochromic film dosimetry, the detector suite includes saturation-corrected (transmission) ionisation chambers [3] as well as screen and bulk scintillator setups, partly with tomographic reconstruction capabilities for 3D dose distribution retrieval. Moreover, non-invasive, single-shot-capable online time-of-flight-based spectral characterisation of filtered proton pulses has proven a powerful tool for beam monitoring as well as dosimetric purposes.
In this presentation the complex and versatile dose delivery system of laser-driven protons at the Draco PW using pulsed solenoids will be discussed. Its characterisation, technological development and improvement as well as the dosimetry suite as a vital part of the precise dose delivery will be addressed, while the presentation by U. Schramm covers recent experimental activities in detail.
[1] T. Ziegler, et al., Proton beam quality enhancement by spectral phase control of a PW-class laser system, https://arxiv.org/abs/2007.11499 (2020)
[2] Brack, et al., Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline, SciRep, 10:9118, (2020)
[3] Gotz M, et al., A new model for volume recombination in plane‐parallel chambers in pulsed fields of high dose‐per‐pulse. Phys Med Biol., 62: 8634, (2017)
KEYWORDS: Hydrogen, Laser beam diagnostics, Laser systems engineering, Plasma, Cryogenics, Ion beams, Computer simulations, Data conversion, Data analysis, Mode locking
The development of high-intensity short-pulse lasers in the Petawatt regime offers the possibility to design new compact accelerator schemes by utilizing high-density targets for the generation of ion beams with multiple 10 MeV energy per nucleon. The optimization of the acceleration process demands comprehensive exploration of the plasma dynamics involved, for example via spatially and temporally resolved optical probing. Experimental results can then be compared to numerical particle-in-cell simulations, which is particularly sensible in the case of cryogenic hydrogen jet targets [1]. However, strong plasma self-emission and conversion of the plasma’s drive laser wavelength into its harmonics often masks the interaction region and interferes with the data analysis. Recently, the development of a stand-alone and synchronized probe laser system for off-harmonic probing at the DRACO laser operated at the Helmholtz-Zentrum Dresden–Rossendorf showed promising performance [2].
Here, we present an updated stand-alone probe laser system applying a compact CPA system based on a synchronized fs mode-locked oscillator operating at 1030 nm, far off the plasma’s drive laser wavelength of 800 nm. A chirped volume Bragg grating (Optigrate Corp) is used as a hybrid stretcher and compressor unit. The system delivers 160 fs pulses with a maximum energy of 0.9 mJ. By deploying the upgraded probe laser system in the laser-proton acceleration experiment with the renewable cryogenic hydrogen jet target, the plasma self-emission could be significantly suppressed while studying the temporal evolution of the expanding plasma jet. Recorded probe images resemble those of z-pinch experiments with metal wires and indicate a sausage-like instability along the jet axis, which will be discussed.
References
[1] L. Obst, et al. Efficient laser-driven proton acceleration from cylindrical and planar cryogenic hydrogen jets. Sci. Rep., 7:10248, 2017.
[2] T. Ziegler, et al. Optical probing of high intensity laser interaction with micron-sized
cryogenic hydrogen jets. Plasma Phys. Control. Fusion, 2018. doi:10.1088/1361-6587/
aabf4f.
[3] C.P. João, et al. Dispersion compensation by two-stage stretching in a sub-400 fs, 1.2 mJ
Yb:CaF2 amplifier. Opt. Express, 22:10097–10104, 2014.
Extreme field gradients intrinsic to relativistic laser plasma interactions enable compact MeV proton accelerators with unique bunch characteristics. Yet, direct control of the proton beam profile is usually not possible. So far, only complex micro-engineering of the relativistic plasma accelerator itself and limited adoption of conventional beam optics provided access to global beam parameters that define propagation.
We present a novel, counter-intuitive all-optical approach to imprint detailed spatial information from the driving laser pulse to the proton bunch.
The concept was motivated by an effect initially observed in an experiment dedicated to laser-driven proton acceleration from a renewable micrometer sized cryogenic Hydrogen jet target at the 150 TW Draco laser at HZDR. A compact, recollimating single plasma mirror was used to enhance the temporal laser contrast, which could be monitored on a single-shot base by means of self-referenced spectral interferometry with extended time excursion (SRSI-ETE) at unprecedented dynamic and temporal range. Unexpectedly, the accelerated proton beam profile showed in this experiment prominent features of the collimated laser beam, such as the shadow of obstacles inserted deliberately in the beam.
In a series of further experiments, the spatial profile of the energetic proton bunch was found to exhibit identical features as the fraction of the laser pulse passing around a target of limited size. The formation of quasi-static electric fields in the beam path by ionization of residual gas in the experimental chamber results in asynchronous information transfer between the laser pulse and the naturally delayed proton bunch.
Such information transfer between the laser pulse and the naturally delayed proton bunch is attributed to the formation of quasi-static electric fields in the beam path by ionization of residual gas. Essentially acting as a programmable memory, these fields provide access to a new level of proton beam manipulation.
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