Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications

Xiaoyu Cheng; Benjamin F. P. McVey; Andrew B. Robinson; Guillaume Longatte; Peter B. O’Mara; Vincent T. G. Tan; Pall Thordarson; Richard D. Tilley; Katharina Gaus; J. Justin Gooding

doi:10.1117/12.2249592

22 February 2017 Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications

Xiaoyu Cheng, Benjamin F. P. McVey, Andrew B. Robinson, Guillaume Longatte, Peter B. O’Mara, Vincent T. G. Tan, Pall Thordarson, Richard D. Tilley, Katharina Gaus, J. Justin Gooding

Author Affiliations +

Proceedings Volume 10078, Colloidal Nanoparticles for Biomedical Applications XII; 100780O (2017) https://doi.org/10.1117/12.2249592
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In this paper we present recent advances in Förster resonance energy transfer (FRET) sensing and bioimaging using nontoxic silicon quantum dots. (SiQDs) In our work, we prepare SiQDs-dye conjugates, with SiQDs serving as the donor which are covalently attached to organic dye acceptors via self-assembled monolayer linkers. Enzymatic cleavage of the peptide leads to changes in FRET response which was monitored using fluorescence lifetime imaging microscopy (FLIM-FRET). The combination of interfacial design and optical imaging presented in this work opens new opportunities for bio-applications using nontoxic silicon quantum dots.

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Xiaoyu Cheng, Benjamin F. P. McVey, Andrew B. Robinson, Guillaume Longatte, Peter B. O’Mara, Vincent T. G. Tan, Pall Thordarson, Richard D. Tilley, Katharina Gaus, and J. Justin Gooding "Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications", Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 100780O (22 February 2017); https://doi.org/10.1117/12.2249592

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