Physical replication and validation of mathematical mitral valve models

Patrick Carnahan; Charles C. X. Yuan; John Moore; Gianluigi Bisleri; Daniel Bainbridge; Terry M. Peters; Elvis C. S. Chen

doi:10.1117/12.3006494

29 March 2024 Physical replication and validation of mathematical mitral valve models

Patrick Carnahan, Charles C. X. Yuan, John Moore, Gianluigi Bisleri, Daniel Bainbridge, Terry M. Peters, Elvis C. S. Chen

Author Affiliations +

Proceedings Volume 12928, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling; 1292807 (2024) https://doi.org/10.1117/12.3006494
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Accurate models of the mitral valve are highly valuable for studying the physiology of the heart and its various pathologies, as well as creating physical replicas for cardiac surgery training. Currently, heart simulator technologies are used which rely on patient-specific data to create valve replicas. Alternatively, mathematical models of the mitral valve have been developed for computational applications. However, there are no studies that mathematically model both the mitral valve’s leaflets and its saddle-shaped annulus in a single design together in current literature. This results in anatomic inaccuracies in current models, as either only the leaflets or the saddle-shaped annulus are realistically modelled. Mathematical models to date have not been replicated as dynamic, physical valves and validated in a heart simulator system. We propose a new parametric representation of the mitral valve based on a combination of valve models from prior literature, combining both accurate leaflet shape, and annular geometry. A physical silicone replica of the model is created and validated in a pulse duplicator. Using a transesophageal echocardiography probe with color Doppler imaging, we demonstrate that our combined model replicates healthy valve behaviour, showing no regurgitation at realistic pressure gradients across the valve.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Patrick Carnahan, Charles C. X. Yuan, John Moore, Gianluigi Bisleri, Daniel Bainbridge, Terry M. Peters, and Elvis C. S. Chen "Physical replication and validation of mathematical mitral valve models", Proc. SPIE 12928, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling, 1292807 (29 March 2024); https://doi.org/10.1117/12.3006494

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