Raman optical tweezers have a wide range of applications in aerosol property measurements, such as moisture absorption and volatility properties. When capturing aerosols with optical tweezers, it has the advantage of non-contact and non-damage to aerosols. However, there is a problem of low capture efficiency of aerosols when aerosol property measurements are performed with Raman optical tweezers, which affects the efficiency of aerosol property measurement experiments. Here, we propose a flow rate control-based method to improve the aerosol capture efficiency. Firstly, we clarify that the most suitable atomization angle is 30 degrees by simulating the flow rate distribution of aerosol in the chamber under different atomization angle conditions. Then, we conduct aerosol capture efficiency validation experiments. Finally, we carry out an aerosol property measurement experiment based on the proposed aerosol capture method. The proposed aerosol flow rate control-based method can improve the capture efficiency not only of aerosols but also of micro- and nanoparticles in vacuum optical tweezer systems.
An optical method for achieving liquid-liquid phase separation (LLPS) was reported. By using optical tweezers (OT) technique, the highly focused laser trap can produce a microdroplet in the mixture of inorganic phosphate buffered saline (PBS) and organic solvent isopropanol. The Raman test method revealed that the phosphate microdroplet was the product of LLPS. The controllable generation of microdroplets can be achieved by adjusting the proportion of two components in the mixture (1:3 to 1:40). With advantages in precise manipulation and controllable growth of single microdroplet, such an OT-based LLPS method promotes potential innovation ideas in the fields of disease treatment, intracellular structures, and droplet microfluidics.
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