Light emitting diode based photoacoustic/ultrasound imaging reveals fast dynamic contrast in liver and changes in blood oxygenation (Conference Presentation)

James Joseph; Mithun Kuniyil Ajith Singh; Naoto Sato; Sarah Bohndiek

doi:10.1117/12.2544317

20 April 2020 Light emitting diode based photoacoustic/ultrasound imaging reveals fast dynamic contrast in liver and changes in blood oxygenation (Conference Presentation)

James Joseph, Mithun Kuniyil Ajith Singh, Naoto Sato, Sarah Bohndiek

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112400Q (2020) https://doi.org/10.1117/12.2544317
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

High power light emitting diodes (LEDs) can serve as fast, robust and affordable excitation sources for photoacoustic imaging. We test the in vivo imaging capabilities of a multi-modal imaging platform that comprises of LED-based photoacoustic (PA) and conventional ultrasound imaging. We characterized the dynamics of a fluorescent contrast agent and modulation of tissue oxygenation in vivo. Fast dynamic PA imaging shows an increase in PA signal with increasing fluorescent agent concentration (Tmax ~ 8 min). Oxygen challenge studies revealed changes in blood oxygenation saturation (SO2) levels in relation to the modulation of breathing air and oxygen.

Conference Presentation

Citation Download Citation

James Joseph, Mithun Kuniyil Ajith Singh, Naoto Sato, and Sarah Bohndiek "Light emitting diode based photoacoustic/ultrasound imaging reveals fast dynamic contrast in liver and changes in blood oxygenation (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400Q (20 April 2020); https://doi.org/10.1117/12.2544317

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