Optical biosensor array based on natural ion channels

Cordelia A. Zimmerer; Hans-Georg Braun; Marco Kitsche; Gerald Steiner; Steffen Friedrich; Reiner Salzer

doi:10.1117/12.508180

1 August 2003 Optical biosensor array based on natural ion channels

Cordelia A. Zimmerer, Hans-Georg Braun, Marco Kitsche, Gerald Steiner, Steffen Friedrich, Reiner Salzer

Proceedings Volume 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II; (2003) https://doi.org/10.1117/12.508180
Event: NDE for Health Monitoring and Diagnostics, 2003, San Diego, California, United States

Abstract

Ion channels are promising biomolecules for sensor applications. They combine high sensitivity with excellent selectivity. Presently the main problem consists in the integration of such ion channels into synthetic matrices but keeping them operative. In this study we report on the development of a microstructured polymer layer as matrix for an ion channel sensor array and an optical method for parallel detection. A thin PMMA layer was prepared by spin coating a gold surface. Small pores with diameter in the range of few micrometers were made by e-beam lithography. FTIR imaging spectroscopy and SPR imaging were used to characterize the quality of microstructured arrays.

Citation Download Citation

Cordelia A. Zimmerer, Hans-Georg Braun, Marco Kitsche, Gerald Steiner, Steffen Friedrich, and Reiner Salzer "Optical biosensor array based on natural ion channels", Proc. SPIE 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II, (1 August 2003); https://doi.org/10.1117/12.508180

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