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7 March 2022 Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography
Yixuan Ming, Zhiyao Xu, Yonatan R. Lewis-Israeli, Brett D. Volmert, Aitor Aguirre, Chao Zhou
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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC119480U (2022) https://doi.org/10.1117/12.2610031
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Organoids play an increasingly important role in in vitro models for studying organ development and disease mechanisms, and drug discovery. Recently, two groups independently developed human heart organoids from human pluripotent stem cells (hPSCs). In this study, we utilized a customized spectral-domain OCT (SD-OCT) to study heart organoids and demonstrated its capability to produce 3D images. Heart organoids formed cavities of various sizes, and complex interconnections were observed as early as on day 6. Heart organoids and the OCT system showed promising insights as an in vitro platform to investigate heart development and diseases mechanisms.
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Yixuan Ming, Zhiyao Xu, Yonatan R. Lewis-Israeli, Brett D. Volmert, Aitor Aguirre, and Chao Zhou "Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480U (7 March 2022); https://doi.org/10.1117/12.2610031
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KEYWORDS
Heart
Optical coherence tomography
Coherence imaging
In vitro testing
3D modeling
Drug discovery
Luminescence
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