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10 December 2024 Measurement of tissue optical properties in the 400 to 700 nm range to assess light penetration depths for laser treatment of upper tract urothelial carcinomas
Himemi Watabe, Yu Shimojo, Asako Shingu, Hidenori Ito, Hideo Fukuhara, Makito Miyake, Keiji Inoue, Kiyohide Fujimoto, Takahiro Nishimura
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Journal of Biomedical Optics, Vol. 29, Issue 12, 125001 (December 2024). https://doi.org/10.1117/1.JBO.29.12.125001
Abstract

Significance

For therapeutic approaches for upper tract urothelial carcinomas, the absorption μa and reduced scattering μs′ coefficients of these tissues are essential parameters to quantitatively evaluate the distribution of light treatment effects.

Aim

The μa and μs′ spectra of the human ureter, fatty tissue, ureteral and renal pelvic carcinomas, and porcine ureter and fatty tissue are measured over 400 to 700 nm to evaluate projected light penetration depths δ.

Approach

The optical properties were determined with a double integrating sphere optical system and inverse Monte Carlo methods. δ was calculated and compared between normal and cancerous human tissues as well as between normal human and porcine tissues.

Results

μa and μs′ spectra of each tissue were determined. The δ of the normal human ureter was less than those of the ureteral and renal pelvic carcinomas, whereas that of the porcine ureter was similar to that of the human ureter over 400 to 600 nm and ∼0.2 times smaller above 600 nm.

Conclusion

Optical properties of human and porcine upper urinary tracts provide insights into light distributions and the validity of ex vivo porcine models in preclinical evaluations of laser treatments.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Himemi Watabe, Yu Shimojo, Asako Shingu, Hidenori Ito, Hideo Fukuhara, Makito Miyake, Keiji Inoue, Kiyohide Fujimoto, and Takahiro Nishimura "Measurement of tissue optical properties in the 400 to 700 nm range to assess light penetration depths for laser treatment of upper tract urothelial carcinomas," Journal of Biomedical Optics 29(12), 125001 (10 December 2024). https://doi.org/10.1117/1.JBO.29.12.125001
Received: 20 August 2024; Accepted: 22 November 2024; Published: 10 December 2024
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KEYWORDS
Adipose tissue
Tissues
Biological samples
Optical properties
Connective tissue
Optical testing
Absorption
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