Availability of the high-performance computing resources makes possible simulations of the neural networks at unprecedented resolution and high biological realism. Creating a microcircuit of the dorsal striatum is discussed on the example of the mouse brain. Models of striatal projection neurons and interneurons are built using multi-objective optimization procedure. Special attention is paid to ensure variability of morpho-electric features within the simulated population of the nerve cells. Synaptic connectivity within the reconstructed microcircuit is anatomically constrained by the morphology of individual cells and further tuned to match the experimentally observed connection probability for all known local projections. Reconstructed microcircuit faithfully reproduces background activity of the striatum as well as the typical response to the external stimulation and can be used to study the striatal dynamics in healthy and diseased states.
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