Now, terahertz (THz) technologies have been actively studied and applied in various biomedical applications including cancer diagnosis. It is related with unique features of THz spectroscopy, such as high sensitivity to water and other polar molecules, the presence of resonant peaks of various biomolecules in the THz frequency range, harmless of THz radiation to biological tissues. In this work, we have investigated different types of gastric tissues using THz spectroscopy and obtain refractive indices in the frequency range from 0.2 to 1 THz. Fourier transform infrared spectroscopy (FT-IR) was also applied in order to see what’s components of tissues make the most significant contribution in optical response and, therefore, allow to discriminate cancer.
Non-invasive diagnostics methods are very helpful for cancer diagnosis and they are a research hotspot in the field of biomedicine. Terahertz (THz) photonics is an emerging technology that can be applied in the field of medical diagnostics. This is due to unique features of THz radiation such as harmlessness to biological tissues, strong absorption by water, ability to identify various biomolecules, etc. In this work we have investigated different types of normal and cancer fresh tissues of the stomach using terahertz time domain spectroscopy in reflection mode. Refractive indices of mucous, serous and tumor stomach tissues were obtained in the frequency range of 0,2 - 1 THz. These optical properties are higher for cancer tissue than for mucosa and lower than for serosa. Thus possibility of discrimination of tumor from normal stomach tissue was demonstrated. This study has practical significance for the field of clinical cancer diagnosis and will help to better understand the specifics of the method of pulsed THz spectroscopy applicable to this field.
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