Structural and functional dysregulation of the retinal microvasculature have been implicated in the pathogenesis of glaucomatous optic neuropathy. To detect relative blood perfusion heterogeneity in the macular circulation in subjects with glaucoma and healthy controls, we used a commercial optical coherence tomography angiography (OCTA) system with a custom post-acquisition image processing software, involving multi-volume registration and averaging. In 10 subjects diagnosed with glaucoma and 5 control subjects, we observed differences among patient groups in retinal vasculature perfusion heterogeneity, as a potential marker for vascular dysregulation.
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