The intraoperative assessment of tumor margins of head and neck cancer is crucial for complete tumor resection and patient outcome. The current standard is to take intraoperatively tumor biopsies for frozen section analysis or to wait for the postoperative final histopathology report. The intraoperative evaluation is time-consuming, subjective, and methodologically limited. Optical methods like hyperspectral imaging (HSI) are of high interest to overcome these limitations. We present a framework to connect in-vivo HSI measurements to ex-vivo histopathological assessments with results as first steps towards the use of HSI as a tool for in-vivo tumor evaluation during head and neck surgery.
Modern medicine faces a major challenge in preventing, diagnosing, and treating cancer, especially in its early stages. Current tools for early detection and minimally invasive treatment are insufficient. Laser-based nonlinear endoscopy combining CARS, SHG, and TPEF emerges as a promising solution for cancer diagnostics by detecting molecular changes in tissue for differentiating cancer from healthy tissue. We developed an endomicroscopic system for head and neck cancer diagnosis and femtosecond laser ablation of tissue. The system has been validated through ex-vivo measurements on patient tissue slices and machine learning methods are being developed for quantitative comparison with standard H&E histopathology.
Acknowledgements:
Funding from the European Community’s Horizon 2020 Programme under the grant agreement No. 860185 (PHAST), No 101016923 (CRIMSON) and from the German Federal Ministry of Education and Research (BMBF): within the project TheraOptik (FKZ 13GW0370E) and LPI (Grant Number 13N15467) is acknowledged.
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