Photobiomodulation (PBM) using near-infrared (NIR)-II light has been shown to enhance anti-cancer immunity by reducing oxidative stress, promoting proliferation, and reducing PD-1 expression in tumor-infiltrating CD8+ T cells, ultimately suppressing tumor progression. Meanwhile, photoimmunotherapy (PIT) using NIR light has also shown promise in cancer treatment, inducing a strong anti-cancer immune response. Combining PBM with laser-based phototherapy, including PIT, could have the potential to amplify their therapeutic effects maximally, offering a promising avenue for developing safe and effective cancer therapies.
Photobiomodulation (PBM) with low-power near-infrared (NIR) light has shown diverse beneficial effects. Recent studies report that PBM also increases bioavailable nitric oxide (NO), which is a critical gaseous mediator for various physiological processes and could be used to treat cardiovascular and cerebrovascular diseases with suppressed endothelial NO production. We explored using NIR-II light (1000-1700 nm) for PBM. NIR-II laser treatment efficiently enhanced NO generation in endothelial cells. Since impaired NO production is also associated with neurological diseases, this novel therapy could be further explored to treat diseases such as traumatic brain injury, sleep disorders, and Alzheimer's disease.
There is solid evidence of diverse beneficial effects of the treatment with low-power near-infrared (NIR) light in the NIR I window (630-900 nm). We have demonstrated PBM with NIR-II window (1061-1301 nm) augments the immune response of the vaccine, but other beneficial effects of NIR-II laser have not been fully explored. In this study, we have shown that NIR-II laser enhances bioavailable NO in endothelial cells. Since a hallmark of endothelial dysfunction is suppressed eNOS with concomitant NO deficiency, NIR-II laser technology could be broadly used to restore endothelial NO and treat or prevent cardiovascular diseases.
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