This paper proposes an improved digital microfluidics (DMF) chip based on a printed circuit board (PCB) to realize the precise control of droplets. Solder mask layer was introduced to the chip as the dielectric layer, and this way can simplify the preparation processes of the chip, and the chip offers reasonable control of the droplet. Combined with the external module, the S protein peptide was screened on the chip. As a result, this PCB-based chip provided a new tool for droplet manipulation. It may have potential applications in drug screening, especially in the field with many repetitive operations.
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