Mr. Jean-Pierre Gehrig Profile

Jean-Pierre Gehrig

at Cinetis SA

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Proceedings Article | 31 January 2001 Paper

New multichannel DSP-based laser Doppler flowmetry analysis system for quantification of ocular blood flow

Benno Petrig, Jean-Pierre Gehrig, Pierre Pompili

Proceedings Volume 4156, (2001) https://doi.org/10.1117/12.413692

KEYWORDS: Digital signal processing, Doppler effect, Blood circulation, Signal processing, Data acquisition, Tissues, Sensors, Data storage, Computing systems, Spatial resolution

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The physiology and pathology of the ocular microcirculation is of interest in several prevalent eye diseases. Quantification of blood flow in ocular tissues at high temporal and spatial resolution, essential for the early detection of alterations during the disease process, requires highly sensitive measurement techniques such as laser Doppler flowmetry (LDF). Spatial resolution is important when attempting to measure blood flow in tissue layers at different depths and can be increased by reducing the probing laser's spot size and using detectors with very small apertures, however, at the expense of lower Doppler signal-to-noise ratio and greater variability of the measurements. To improve LDF signal-to-noise, while retaining the increased spatial resolution of small measuring volumes, a multi- channel approach was undertaken. A new LDF analysis card was designed using a TMS320C31 digital signal processor providing independent LDF analysis of up to 4 analog input channels. Two cards are used in parallel to analyze the output signals of a compound 7-channel detector. Analysis results of all channels are continuously uploaded to a PC which averages the channels and provides the user interface.

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