Mr. Jorge Rial-Ferrario Profile

Jorge Rial-Ferrario

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Proceedings Article | 18 June 2024 Presentation + Paper

Development and characterization of a hyperspectral LCTF-based colposcopic system

Carlos Vega, Nerea Marquez-Suarez, Raquel Leon, María Castro-Fernandez, Guillermo Socorro-Marrero, Himar Fabelo, Jorge Rial-Ferrario, Gustavo Callico

Proceedings Volume 13016, 130160E (2024) https://doi.org/10.1117/12.3017399

KEYWORDS: Tunable filters, Optical filters, Signal to noise ratio, Spectral response, Sensors, Cameras, Liquid crystals, Near infrared, Manufacturing, Hyperspectral imaging, Cervical cancer, Image acquisition

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The early detection of precancerous cervical lesions is essential to improve patient treatment and prognosis. Hyperspectral (HS) imaging (HSI) has demonstrated a high potential to become a new non-invasive and label-free imaging technique in the medical field for performing quick diagnosis of different diseases. This study presents the research and development process to integrate and characterize a KURIOS-XE2 filter (Thorlabs, Inc., NJ, USA), based in a liquid crystal tunable filter (LCTF) technology, into an existing colposcope (C5, OPTOMIC, Spain). The main goal was to capture spectral information in the near infrared range (650 to 1100nm) by using a monochrome camera and acquiring 90 spectral wavelengths with a spectral resolution of 5nm. Two different integration strategies were studied: i) filtering the emitted light by the sensor and ii) filtering the received light by the sensor, evaluating their respective benefits and limitations. Furthermore, a custom software was developed for HS image acquisition, integrating a variable acquisition time per wavelength, which allows improving the signal-to-noise ratio at wavelengths where the system presents lower quantum efficiency. The proposed system simplifies the adaptation of existing optical systems to HSI technology, improving the signal-to-noise ratio in the studied spectral range respect to other approaches. The results were compared against a previous custom implementation based on a Snapscan camera (IMEC, Belgium), covering the visual and near infrared and highlighting the advantages and limitations of both technologies for the development of a HS colposcope system targeting early detection of precancerous cervical lesions during routine clinical practice.

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