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Lei Shi

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Proceedings Article | 7 September 2023 Paper

Population pharmacokinetics of levetiracetam in juvenile epilepsy patients in Shaanxi province

Jinming Zhang, Lei Shi, Jingjie Yu, Qianting Yang

Proceedings Volume 12789, 1278936 (2023) https://doi.org/10.1117/12.2692624

KEYWORDS: Plasma, Data modeling, Mathematical modeling

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To establish a population pharmacokinetic model of levetiracetam for minors in Shaanxi Province, determine the covariates that affect the pharmacokinetic parameters and the mathematical relationship between them. One hundred and forty samples of patient blood concentrations were collected from minors in Shaanxi Province, and 77 samples were included. The population pharmacokinetic model was established by NONMEM software and validated by the bootstrapping method. A one-compartment model with first-order absorption best described the data. In the final model, the typical population values of CL/F, V/F, and Ka are 2.52 L/h, 23.9 L and 1.28 ℎ⁻¹ respectively, and age is the only remaining covariate affecting the pharmacokinetic parameters of levetiracetam. This model can be used to predict individual palsma concentrations and help formulate a clinical individual drug administration plan for a specific patient population.

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