Dr. Michael Bertilson Profile

Dr. Michael Bertilson

at Eclipse Optics

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Proceedings Article | 1 April 2024 Presentation + Paper

Non-prewhitening observer applied on grating-based and grating-less phase-contrast imaging: a simulation study

Rickard Brunskog, Michael Bertilson, Olov von Hofsten, Mats Persson

Proceedings Volume 12925, 129250H (2024) https://doi.org/10.1117/12.3005509

KEYWORDS: Sensors, Signal attenuation, X-ray computed tomography, Visibility, Signal detection, Phase reconstruction, X-rays, Computed tomography, Medical imaging

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When implementing differential phase-contrast imaging with current CT detectors the limited pixel size forces one to scan an analyser-grating in front of the detector to resolve the interference pattern. This simulation study compares the approach of using an analyser-grating and the approach of using a high-resolution detector to directly resolve the interference pattern by applying the non-prewhitening observer on dose-matched simulated CT scan reconstructions of the two approaches. A phantom with two concentric cylinders is used and 1000 CT scans are generated with the inner cylinder present and not present. The non-prewhitening observer is applied to the samples and the ROC curve is extracted, together with the results of a 2AFC test, the CNR, and the detectability. The high-resolution approach shows a 20% increase in the phase AUC compared to the grating-based approach, with a similar increase in the 2AFC test score. The image CNR of the phase shows an increase of 134%, with the detectability increasing by 138% when compared to the grating based approach. An ultra-high-resolution detector, capable of directly resolving the interference pattern of differential phase-contrast imaging could change medical imaging CT as we know it. The implementation in a clinical CT would be simpler, could lower cost, and increase the dose-efficiency due to the obviation of the G2-grating, and at the same time provide an additional two diagnostic signals.

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