Mr. Nicolas Vasquez-Tobar Profile

Nicolas Vasquez-Tobar

at Univ. de Santiago

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 6 March 2023 Paper

An automatic method for detection of evoked events in the brain during spinal cord stimulation

Nicolás Vásquez-Tobar, Mario Cáceres, Romulo Fuentes, Leonel Medina

Proceedings Volume 12567, 1256719 (2023) https://doi.org/10.1117/12.2669787

KEYWORDS: Brain, Wavelets, Spinal cord, Signal detection, Pulse signals, Animals, Parkinson disease, Electrodes, Wavelet transforms, Performance modeling

Read Abstract +

Parkinson’s disease (PD) is a neurodegenerative brain disorder that mainly affects the elderly population and currently has no cure, only palliative treatments. Recently, spinal cord stimulation (SCS) showed great promise in the treatment of certain PD symptoms. In this semi-invasive technique, pulses of current are delivered to the spinal cord via electrodes implanted in the epidural space. However, the effects of SCS in the brain are poorly understood. In this work, we developed a method for detection of electrophysiological events in the brain evoked by SCS pulses, and analyzed the latency of such events under different experimental conditions. We performed in vivo recordings of local field potentials using 64 microelectrodes implanted in different brain areas of a rat model of PD, and during active and inactive states, and with and without administration of L-dopa. The signals were pre-processed and divided into windows centered around the stimulation pulses, in which we detected the evoked events using two approaches: the Hampel identifier and the wavelet transform. Next, we measured the latency of the response evoked in the brain with respect to the applied pulse. The Hampel method detected events in about 31% of trials, and the wavelet method in about 42% of trials. In addition, we found that movement had a statistical significant effect on the measured latency but only when L-dopa was administered to the animal. The differences in latency suggest that there may be a trajectory of neuronal activation in the brain in response of SCS. Our results may have implications in the design of more effective SCS strategies for the treatment of PD.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years