KEYWORDS: Statistical analysis, Gold nanoparticles, Modeling, Data modeling, COVID 19, Surface plasmons, Diseases and disorders, Design and modelling, Demodulation, Control systems
Performance of paper-based rapid tests is limited by their poor limit of detection and binary response. We have developed a low-cost end-user device that overcomes the classic limitations of rapid tests. The Arduino-based hand-held device excites rapid test gold nanoparticles with modulated 532nm LED while recording their thermal wave response with low-cost thermometer ICs. Validation studies on COVID-19 antibodies and THC (psychoactive constituent of cannabis) in saliva demonstrates ability of the innovation in quantifying analyte concentrations and enhancing the limit of detection by over an order of magnitude.
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