The monitoring of cardiopulmonary functions is essential to diagnose various heart diseases. Moreover, with the spread of the novel coronavirus which is particularly fatal to human life due to ‘silent hypoxia’, the monitoring of cardiopulmonary is being more and more important. We here demonstrate a multimodal necklace capable of monitoring blood oxygenation but also blood flow rate, velocity, and possibly blood pressure. The necklace consists of pulse oximeter sensors and single-element ultrasound transducers. The estimation of a pulse wave velocity (PWV), which is highly correlated with blood pressure, is investigated by exploiting the pulse oximeter sensor and ultrasound transducer in this study. The developed multimodal necklace was evaluated through in vivo study. The results showed that both the chemical and mechanical information of cardiopulmonary function can be monitored with low hardware complexity and resource using the multimodal necklace.
To measure the metastatic or mechanical properties of cancer cells, various methods have been implemented. However, these methods have some shortcomings that they are time-consuming, require direct contact with cells, and are measuring accuracy is sensitive to boundary conditions of the sample. To overcome these shortcomings, in this study, we developed a cell mechanical property measurement system based on the quantitative phase imaging system and ultrasound stimulation system capable of the precise determination of the invasion potential of cancer cells. By using a developed system, it is possible to successfully measure the change in thickness due to the ultrasound stimulation of various types of cancer cells according to various acoustic pressure. In addition, the time to recover the original thickness after ultrasound stimulation was also measured with a high-speed camera to characterize the mechanical properties of the cancer cells.
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