Dr. Shuang Wang Profile

Dr. Shuang Wang

at Northwest Univ

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 20 December 2019 Paper

Utilizing Raman spectral imaging for distinguishing breast cancer from hyperplasia

Heping Li, Yu Ren, Dongliang Song, Fan Yu, Siyuan Jiang, Shuang Wang

Proceedings Volume 11209, 1120929 (2019) https://doi.org/10.1117/12.2548124

KEYWORDS: Tissues, Raman spectroscopy, Proteins, Breast cancer, Breast, Cancer, Imaging spectroscopy, Confocal microscopy, Tumors

Read Abstract +

Breast cancer is one of the most common malignant tumors among female cancer patients. The clinical diagnosis of breast cancer is mainly through biopsy, X-ray, color doppler ultrasound and nuclear magnetic resonance technology, which has a long-time examination and a high-rate misdiagnosis. In this work, we used confocal Raman microspectroscopy imaging (CRMI) to identify the spectra-pathological features of infiltrating ductal carcinoma (IDC) and the hyperplasia tissue. After point-scanned the lesion site, the obtained spectral set was reconstructed for further pathologic visualization by K-means clustering analysis (KCA). The main differences between the cancerous tissue and the hyperplasia tissue are existed at the spectral feature of lipid and protein. The peak intensities of protein at 748, 1000, 1320, 1618 cm^-1 in the cancerous tissue was higher than that in the hyperplasia tissue, whereas the protein Raman peaks at 859 cm^-1 was lower in the cancerous tissue than that in the hyperplasia tissue. While, the lipid content in the 1450, 2880, 2926 cm^-1 were lower than that in the hyperplasia tissue. The content of nucleic acid in 748 cm^-1 cancerous tissue was higher than that in hyperplasia tissue, and there was an additional peak of 1572 cm^-1 presented in hyperplasia tissue. The reconstructed pathological Raman image provided both compositional and structural information for IDC progression. The achieved results lay a foundation for understanding the pathological changes of breast cancer in vivo.

Proceedings Article | 20 December 2019 Paper

Inverse spatially offest Raman spectroscopy and its applications sub-surface material detections

Fan Yu, Heping Li, Dongliang Song, Jie Li, Qingli He, Shuang Wang

Proceedings Volume 11209, 1120928 (2019) https://doi.org/10.1117/12.2548118

KEYWORDS: Raman spectroscopy, Tissues, Axicons, Tissue optics, Chemical analysis

Read Abstract +

Spatially offset Raman spectroscopy (SORS) is a new proposed technique for recovering Raman spectra from up to several millimeters beneath the surface of turbid media. Here, we presented a home-made modular inverse spatially offset Raman spectroscopy (Inverse SORS) system, which is used to acquire chemical specific information on deep layers of biological tissue. In order to demonstrate the performance of presented system, a two-layer biological model was adopted by applying paracetamol powders in pork tissue with 4 mm and 8 mm depth. The results from the model suggest that Inverse SORS not only can acquire Raman features from upper layer tissue, it could also detect the Raman signal from paracetamol powders under 8mm tissue layer using source-detector separations of up to 9 mm. After system optimization, the proposed system and its analytical methodology pave the way for a range of new applications for Raman spectroscopy, including in vivo diagnosis, non-invasive probing of pharmaceutical products in quality control and in tissue-drug interactions.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years