Mr. Sinan Li Profile

Sinan Li

at Verasonics Inc

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SPIE Journal Paper | 1 December 2013 Open Access

Viscosity measurement based on shear-wave laser speckle contrast analysis

Yi Cheng, Sinan Li, Robert Eckersley, Daniel Elson, Meng-Xing Tang

JBO, Vol. 18, Issue 12, 121511, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.121511

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Tissue viscosity is correlated with tissue pathological changes and provides information for tissue characterization. In this study, we report an optical method to track continuous shear-wave propagation at centimeter depths in an optically turbid medium. Shear-wave attenuation coefficients were measured at multiple frequencies using shear-wave laser speckle contrast analysis (SW-LASCA) to quantitatively estimate tissue viscosity using the Voigt model. Shear waves were generated within tissue-mimicking phantoms by an amplitude-modulated ultrasound (modulation frequency: 100 to 600 Hz) and tracked by time-resolved laser speckle contrast difference received on a charged-coupled device camera. Averaged contrast difference over a selected time window was related to shear-wave amplitude and used to calculate the shear-wave attenuation coefficient. Phantoms of varying viscosities (0.1 and 0.3 Pa s) were studied. Attenuation coefficients for different shear-wave frequencies (100 to 600 Hz) were calculated. Derived viscosity values had a maximum standard deviation of 9%, and these values were consistent with the independent measurements reported in a previous study using nonoptical methods.

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