As a multimodal approach, optical coherence tomography (OCT) and Raman spectroscopy (RS) are combined. The acquired morpho-molecular tissue information is not only used for improved clinical diagnostics, but furthermore for investigation, interpretation and understanding of signal origin during ex-vivo as well as in-vivo investigation. We present co-localized, endoscopically acquired OCT and RS data on bladder cancer biopsies. Ground truth is histopathological examination. These findings contribute to interpretation of in-vivo data acquired with endoscopic imaging systems. This approach not only opens a new way of interpretation of both modalities but enables access to clinical relevant information, which is nowadays not available in-situ.
Using the multimodal combination of optical coherence tomography (OCT) with Raman spectroscopy (RS) for obtaining morpho-molecular tissue characteristics of suspicious bladder cancer lesions for improved diagnostics and signal origin characterization.
We present endoscopically acquired co-localized OCT-RS data on bladder cancer biopsies. The correlated OCT and RS data enables a new way of interpretation and understanding of signal origin for both imaging modalities. Histopathological findings serve as ground truth. Molecular signal contributions can be directly correlated to identified morphological features from the OCT and lead to a better understanding of underlying biological structures.
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