Dr. Wihan Kim Profile

Dr. Wihan Kim

Assistant Research Engineer at Univ of Southern Califonia

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Author

Publications (15)

Proceedings Article | 19 June 2024 Presentation

Optical coherence tomography as a tool for interrogating pathologies of the tympanic membrane and middle ear

Marcela Moran, Zihan Yang, Wihan Kim, Ryan Long, John Oghalai, Brian Applegate

Proceedings Volume PC13009, PC1300904 (2024) https://doi.org/10.1117/12.3017301

KEYWORDS: Ear, Optical coherence tomography, Pathology, Vibration, Standards development, Medical imaging, Imaging systems, Image processing, System integration, Scanning probe lithography

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Proceedings Article | 13 March 2024 Presentation + Paper

Analysis of ear symmetry as a diagnostic tool enabled by optical coherence tomography

Zihan Yang, Wihan Kim, Marcela Morán, Ryan Long, John Oghalai, Brian Applegate

Proceedings Volume 12818, 1281802 (2024) https://doi.org/10.1117/12.3003397

KEYWORDS: Ear, Optical coherence tomography, Image registration, 3D image processing, Image processing, Diseases and disorders, Quantitative analysis, Imaging systems, Diagnostics, Matrices

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Proceedings Article | 13 March 2024 Poster + Paper

Contrast-enhanced optical coherence tomography based on spatial frequency analysis applied to the murine cochlea

Zihan Yang, Wihan Kim, Patricia Quiñones, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300L (2024) https://doi.org/10.1117/12.3005760

KEYWORDS: Optical coherence tomography, Cochlea, Spatial frequencies, Tissues, Image contrast enhancement, Visualization, Spectral density

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Proceedings Article | 13 March 2024 Presentation + Paper

Hand-held optical coherence tomography endoscope and stitching algorithm for imaging the human cochlea via the round window

Julianna Bordas, Wihan Kim, Michael Serafino, Jack Tang, Dorothy Pan, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300O (2024) https://doi.org/10.1117/12.3005704

KEYWORDS: Endoscopes, Windows, Ear, Optical coherence tomography, Cochlea, Diseases and disorders, Biological imaging, Detection and tracking algorithms, Algorithm development, X-ray computed tomography

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Proceedings Article | 8 March 2023 Presentation + Paper

Development of a hand-held OCT laryngoscope for reconstruction of 4-D vocal fold dynamics

Anna Wisniowiecki, Wihan Kim, Frank Macias-Escriva, Diego Razura, Michael Johns, Brian Applegate

Proceedings Volume 12367, 1236702 (2023) https://doi.org/10.1117/12.2652767

KEYWORDS: Optical coherence tomography, Reconstruction algorithms, Vibration, Diagnostics, In vivo imaging, Visualization, Algorithm development, Microelectromechanical systems, Endoscopy, Dichroic mirrors

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Proceedings Article | 7 March 2022 Presentation + Paper

Development of a 3D vibrometry system for vector of motion measurements in the living cochlea

Derek Liu, Wihan Kim, Sangmin Kim, Kumara Ratnayake, Scott Mattison, John Oghalai, Brian Applegate

Proceedings Volume 11948, 1194809 (2022) https://doi.org/10.1117/12.2612280

KEYWORDS: Vibrometry, Optical coherence tomography, Motion measurement, Mechanics, Image registration, Image processing

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Proceedings Article | 7 March 2022 Presentation

Dual-wavelength excitation multispectral autofluorescence lifetime imaging handheld probe for label-free metabolic clinical imaging of the oral mucosa

Gabriel Tortorelli, Rodrigo Cuenca Martinez, Michael Serafino, Wihan Kim, Brian Applegate, Javier Jo

Proceedings Volume PC11935, PC1193508 (2022) https://doi.org/10.1117/12.2608936

KEYWORDS: Multispectral imaging, Mirrors, Lenses, Tissues, Time resolved spectroscopy, Relays, Objectives, Medicine, Luminescence, Human subjects

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SPIE Journal Paper | 30 September 2020 Open Access

Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging

Xi Chen, Wihan Kim, Michael Serafino, Zheng Tan, Javier Jo, Brian Applegate

JBO, Vol. 25, Issue 09, 096010, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096010

KEYWORDS: Optical coherence tomography, Endoscopes, Fluorescence lifetime imaging, Luminescence, Cladding, Imaging systems, Arteries, Absorption, Silica, Polishing

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Significance: Detailed biochemical and morphological imaging of the plaque burdened coronary arteries holds the promise of improved understanding of atherosclerosis plaque development, ultimately leading to better diagnostics and therapies. Aim: Development of a dual-modality intravascular catheter supporting swept-source optical coherence tomography (OCT) and frequency-domain fluorescence lifetime imaging (FD-FLIM) of endogenous fluorophores with UV excitation. Approach: We instituted a refined approach to endoscope development that combines simulation in a commercial ray tracing program, fabrication, and a measurement method for optimizing ball-lens performance. With this approach, we designed and developed a dual-modality catheter endoscope based on a double-clad fiber supporting OCT through the core and fluorescence collection through the first cladding. We varied the relative percent of UV excitation launched into the core and first cladding to explore the potential resolution improvement for FD-FLIM. The developed catheter endoscope was optically characterized, including measurement of spatial resolution and fluorescent lifetimes of standard fluorophores. Finally, the system was demonstrated on fresh ex vivo human coronary arteries. Results: The developed endoscope was shown to have optical performance similar to predictions derived from the simulation approach. The FLIM resolution can be improved by over a factor of 4 by primarily illuminating through the core rather than the first cladding. However, time-dependent solarization losses need to be considered when choosing the relative percentage. We ultimately chose to illuminate with 7% of the power transmitting through the core. The resulting catheter endoscope had 40-μm lateral resolution for OCT and <100 μm lateral resolution for FD-FLIM. Images of ex vivo coronary arteries are consistent with expectations based on histopathology. Conclusions: The results demonstrate that our approach for endoscope simulation produces reliable predictions of endoscope performance. Simulation results guided our development of a multimodal OCT/FD-FLIM catheter imaging system for investigating atherosclerosis in coronary arteries.

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Proceedings Article | 19 July 2019 Paper

Stereo microscope based OCT system capable of subnanometer vibrometry in the middle ear

Wihan Kim, Sangmin Kim, John Oghalai, Brian Applegate

Proceedings Volume 11078, 110780G (2019) https://doi.org/10.1117/12.2527222

KEYWORDS: Optical coherence tomography, Ear, Microscopes, Imaging systems, Vibrometry, Distortion, Diagnostics, Biomedical engineering, Coherence imaging

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Proceedings Article | 15 March 2018 Presentation

Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles (Conference Presentation)

Jorge Palma-Chavez, Wihan Kim, Brian Applegate, Phapanin Charoenphol, Javier Jo

Proceedings Volume 10508, 105080F (2018) https://doi.org/10.1117/12.2287469

KEYWORDS: Particles, Optical coherence tomography, Molecular imaging, Arteries, Molecules, Light scattering, Chemical vapor deposition, Image resolution, Crystals, Imaging systems

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Proceedings Article | 14 March 2018 Presentation

Automatic detection of macrophages/foam cells in coronary atherosclerotic plaques based on fluorescence lifetime imaging (FLIM) (Conference Presentation)

Jose Rico-Jimenez, Michael Serafino, Xi Chen, Sebina Shrestha, Wihan Kim, Brian Walton, Brian Applegate, Javier Jo

Proceedings Volume 10471, 1047105 (2018) https://doi.org/10.1117/12.2288606

KEYWORDS: Fluorescence lifetime imaging, Multispectral imaging, Foam, Microscopy, Image analysis, Machine learning, Tissues, Receivers, Statistical analysis

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Proceedings Article | 14 March 2018 Presentation

Design and validation of the ball lens-based intravascular catheter for fluorescence lifetime imaging microscopy of atherosclerosis (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Zheng Tan, Brian Walton, L. Maximilian Buja, Jessie Adame, Javier Jo, Brian Applegate

Proceedings Volume 10471, 1047102 (2018) https://doi.org/10.1117/12.2287447

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Endoscopes, Luminescence, Endoscopy, Tissues, Fiber optics, Performance modeling, Zemax, Polishing

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Proceedings Article | 25 January 2018 Presentation

Design and validation of the ball lens-based intravascular catheter for fluorescence lifetime imaging microscopy of atherosclerosis (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Javier Jo, Brian Applegate

Proceedings Volume 9689, 968932 (2018) https://doi.org/10.1117/12.2211764

Proceedings Article | 1 May 2017 Presentation

Toward intravascular morphological and biochemical imaging of atherosclerosis with optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIM) (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Brian Walton, Javier Jo, Brian Applegate

Proceedings Volume 10060, 1006007 (2017) https://doi.org/10.1117/12.2256676

KEYWORDS: Shortwaves, Optical coherence tomography, Fluorescence lifetime imaging, Imaging systems, Endoscopes, Infrared imaging, Lens design, Arteries, Therapeutics, Near ultraviolet

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Proceedings Article | 26 April 2016 Presentation

Pump-probe optical coherence tomography using microencapsulated methylene blue as a contrast agent (Conference Presentation)

Wihan Kim, Erin Zebrowski, Hazel Lopez, Brian Applegate, Phapanin Charoenphol, Javier Jo

Proceedings Volume 9697, 969722 (2016) https://doi.org/10.1117/12.2214829

KEYWORDS: Optical coherence tomography, Imaging systems, Molecules, Receptors, Biochemistry, Visualization, In vivo imaging, Molecular lasers, Semiconductor lasers, Mirrors

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Showing 5 of 15 publications

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