Dr. Zarfishan Tahir Profile

Dr. Zarfishan Tahir

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 2 March 2022 Paper

Tuberculosis diagnosis from sputum using Raman spectroscopy

Ubaid Ullah, Zarfishan Tahir, Obaidullah Qazi, Shaper Mirza, M. Imran Cheema

Proceedings Volume 11957, 1195703 (2022) https://doi.org/10.1117/12.2608594

KEYWORDS: Raman spectroscopy, Sensors, Diagnostics, Principal component analysis, Optical filters, Spectroscopy, Sensor performance, Optical sensors, Machine learning, Bacteria

Read Abstract +

Tuberculosis (TB) is a deadly disease that causes 1.4 million deaths per year. It is crucial to diagnose and isolate TB patients in the early stages to control this contagious disease. The current gold standard test for TB detection is the culture of a patients' sputum. Although the culture test provides fair accuracy, it takes days to weeks to produce results and needs trained laboratory personals. Here, we demonstrate an optical sensor that uses Raman spectroscopy to detect TB via sputum samples. We collected and prepared sputum samples of potential TB patients in a controlled environment, conducted culture tests, and labeled them as TB-positive and TB-negative samples. We then acquired Raman spectrums of the prepared samples using a 785 nm laser spectroscopy setup, employed principal component analysis (PCA) on the spectroscopic data, and found TB-related unique features which form the basis of TB diagnosis. To evaluate the sensor performance, we tested 40 TB patients, of which 17 were TB-positive and 23 TB-negative. The sensor judiciously classified the two groups with an accuracy of 95%. The proposed sensor is a step towards a rapid, non-invasive, technician-free, and portable TB diagnostic point-of-care device.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years