Dr. Daniel Milej Profile

Dr. Daniel Milej

Research Associate at Lawson Health Research Institute

SPIE Involvement:

Author

Area of Expertise:

Fluorescence , Biomedical imaging , Biophotonics , Time-resolved measuremnts , Tissue optics

Websites:

Personal Website | Company Website

Publications (27)

SPIE Journal Paper | 3 October 2024 Open Access

All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion

Leena Shoemaker, Saeed Samaei, Graham Deller, Danny J. J. Wang, Daniel Milej, Keith St. Lawrence

NPh, Vol. 11, Issue 04, 045002, (October 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.4.045002

KEYWORDS: Near infrared spectroscopy, Hypoxia, Cerebral blood flow, Magnetic resonance imaging, Blood circulation, Calibration, Neurophotonics, Tissues, Brain, Oxygen

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SPIE Journal Paper | 3 May 2024 Open Access

Assessing changes in regional cerebral hemodynamics in adults with a high-density full-head coverage time-resolved near-infrared spectroscopy device

Farah Kamar, Leena Shoemaker, Rasa Eskandari, Daniel Milej, Darren Drosdowech, John Murkin, Keith St. Lawrence, Jason Chui, Mamadou Diop

JBO, Vol. 29, Issue S3, S33302, (May 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S3.S33302

KEYWORDS: Surgery, Brain, Hemodynamics, Near infrared spectroscopy, Oxygenation, Tunable filters, Head, Skin, Bandpass filters, Wavelets

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SignificanceCerebral oximeters have the potential to detect abnormal cerebral blood oxygenation to allow for early intervention. However, current commercial systems have two major limitations: (1) spatial coverage of only the frontal region, assuming that surgery-related hemodynamic effects are global and (2) susceptibility to extracerebral signal contamination inherent to continuous-wave near-infrared spectroscopy (NIRS).AimThis work aimed to assess the feasibility of a high-density, time-resolved (tr) NIRS device (Kernel Flow) to monitor regional oxygenation changes across the cerebral cortex during surgery.ApproachThe Flow system was assessed using two protocols. First, digital carotid compression was applied to healthy volunteers to cause a rapid oxygenation decrease across the ipsilateral hemisphere without affecting the contralateral side. Next, the system was used on patients undergoing shoulder surgery to provide continuous monitoring of cerebral oxygenation. In both protocols, the improved depth sensitivity of trNIRS was investigated by applying moment analysis. A dynamic wavelet filtering approach was also developed to remove observed temperature-induced signal drifts.ResultsIn the first protocol (28±5 years; five females, five males), hair significantly impacted regional sensitivity; however, the enhanced depth sensitivity of trNIRS was able to separate brain and scalp responses in the frontal region. Regional sensitivity was improved in the clinical study given the age-related reduction in hair density of the patients (65±15 years; 14 females, 13 males). In five patients who received phenylephrine to treat hypotension, different scalp and brain oxygenation responses were apparent, although no regional differences were observed.ConclusionsThe Kernel Flow has promise as an intraoperative neuromonitoring device. Although regional sensitivity was affected by hair color and density, enhanced depth sensitivity of trNIRS was able to resolve differences in scalp and brain oxygenation responses in both protocols.

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Proceedings Article | 15 August 2023 Paper

Optical assessment of the response in cerebral metabolism to mean arterial pressure during the transition onto cardiopulmonary bypass

Marianne Suwalski, Daniel Milej, Ajay Rajaram, Mamadou Diop, John Murkin, Jason Chui, Keith St. Lawrence

Proceedings Volume 12627, 126271B (2023) https://doi.org/10.1117/12.2670594

KEYWORDS: Mode conditioning cables, Brain mapping, Surgery, Oxygen, Brain, Near infrared spectroscopy, Brain tissue, Blood circulation, Spectroscopy, Cerebral blood flow

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Proceedings Article | 9 August 2023 Paper

Importance of depth-enhanced optical methods for measuring cerebral hemodynamics during transient hypotension

Daniel Milej, Leena Shoemaker, Jigneshkumar Mistry, Keith St. Lawrence

Proceedings Volume 12628, 126280P (2023) https://doi.org/10.1117/12.2666077

KEYWORDS: Oxygenation, Optical testing, Hemodynamics, Tissue optics, Near infrared spectroscopy, Tissues, Data acquisition, Contamination, Cerebral blood flow, Brain

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SPIE Journal Paper | 5 June 2023 Open Access

Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension

Leena Shoemaker, Daniel Milej, Jigneshkumar Mistry, Keith St. Lawrence

NPh, Vol. 10, Issue 02, 025013, (June 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.025013

KEYWORDS: Blood circulation, Near infrared spectroscopy, Brain, Data modeling, Spectroscopy, Hemodynamics, Contamination, Oxygenation, Data acquisition, Neurophotonics

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Proceedings Article | 15 March 2023 Presentation + Paper

Effects of blood pressure on brain metabolism during cardiopulmonary bypass

Marianne Suwalski, Daniel Milej, Ajay Rajaram, Mamadou Diop, John Murkin, Jason Chui, Keith St. Lawrence

Proceedings Volume 12364, 123640H (2023) https://doi.org/10.1117/12.2649998

KEYWORDS: Surgery, Blood pressure, Near infrared spectroscopy, Brain, Oxygen, Data acquisition, Spectroscopy, Tissues

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Proceedings Article | 7 March 2023 Presentation + Paper

Sensitivity of a full-head coverage high-density time-resolved NIRS device to carotid compressions

Farah Kamar, Leena Shoemaker, Androu Abdalmalak, Daniel Milej, Keith St. Lawrence, Mamadou Diop

Proceedings Volume 12376, 123760H (2023) https://doi.org/10.1117/12.2646633

KEYWORDS: Near infrared spectroscopy, Oxygenation, Brain, Surgery, Cerebral blood flow, Oximetry, Oximeters

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Proceedings Article | 7 March 2023 Presentation + Paper

Assessing extracerebral contamination in cerebral blood flow pulsatility measured by diffuse correlation spectroscopy

Jigneshkumar Mistry, Leena Shoemaker, Daniel Milej, Keith St. Lawrence

Proceedings Volume 12376, 123760G (2023) https://doi.org/10.1117/12.2650380

KEYWORDS: Modulation, Contamination, Blood circulation, Spectroscopy, Cerebral blood flow, Data modeling, Data acquisition, Autocorrelation, Head, Brain

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SPIE Journal Paper | 20 July 2022 Open Access

Assessing the relationship between the cerebral metabolic rate of oxygen and the oxidation state of cytochrome-c-oxidase

Daniel Milej, Ajay Rajaram, Marianne Suwalski, Laura B. Morrison, Leena Shoemaker, Keith St. Lawrence

NPh, Vol. 9, Issue 03, 035001, (July 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.3.035001

KEYWORDS: Oxygen, Near infrared spectroscopy, Mode conditioning cables, Brain, Neurophotonics, Oxidation, Tissues, Spectroscopy, Ischemia, Blood circulation

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SPIE Journal Paper | 17 May 2021 Open Access

Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy

Daniel Milej, Androu Abdalmalak, Ajay Rajaram, Amandeep Jhajj, Adrian Owen, Keith St. Lawrence

JBO, Vol. 26, Issue 05, 056003, (May 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.5.056003

KEYWORDS: Photons, Near infrared spectroscopy, Hemodynamics, Brain, Statistical analysis, Contamination, Sensors, Picosecond phenomena, Data acquisition, Signal detection

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Proceedings Article | 5 March 2021 Presentation

Cerebral perfusion and metabolic neuromonitoring during cardiopulmonary bypass

Ajay Rajaram, Marianne Suwalski, Daniel Milej, Lawrence C. Yip, Linrui Ray Guo, Michael W. Chu, Jason Chui, Mamadou Diop, John Murkin, Keith St. Lawrence

Proceedings Volume 11639, 116391G (2021) https://doi.org/10.1117/12.2578986

KEYWORDS: Mode conditioning cables, Surgery, Near infrared spectroscopy, Brain, Traumatic brain injury, Tissues, Spectroscopy, Oxygen, Oxidation

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Proceedings Article | 5 March 2021 Presentation + Paper

Combining time-resolved near-infrared spectroscopy with regression analysis to improve the reconstruction of cerebral hemodynamic responses

Daniel Milej, Androu Abdalmalak, Ajay Rajaram, Marianne Suwalski, Keith St. Lawrence

Proceedings Volume 11639, 116390R (2021) https://doi.org/10.1117/12.2577923

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Photons, Tissues, Brain, Sensors, Reflectivity, Magnetic resonance imaging, Data acquisition

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Proceedings Article | 5 March 2021 Presentation + Paper

Assessing the ability to monitor cerebral blood flow and oxygen consumption by combining time-resolved near-infrared and diffuse correlation spectroscopy

Daniel Milej, Androu Abdalmalak, Ajay Rajaram, Keith St. Lawrence

Proceedings Volume 11639, 1163918 (2021) https://doi.org/10.1117/12.2577933

KEYWORDS: Near infrared spectroscopy, Cerebral blood flow, Spectroscopy, Oxygen, Time resolved spectroscopy, Data modeling, Contamination, Brain, Blood circulation, Tissue optics

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Proceedings Article | 5 March 2021 Presentation

NNeMo (Neonatal NeuroMonitor): a non-invasive brain monitor for continuous acquisition of cerebral blood flow and cytochrome c oxidase in the premature brain

Ajay Rajaram, Lawrence C. Yip, Marianne Suwalski, Daniel Milej, Lilian Kebaya, Matthew Kewin, Mamadou Diop, Sandrine de Ribaupierre, Soume Bhattacharya, Keith St. Lawrence

Proceedings Volume 11639, 1163916 (2021) https://doi.org/10.1117/12.2578721

KEYWORDS: Brain, Cerebral blood flow, Near infrared spectroscopy, Mode conditioning cables, Traumatic brain injury, Spectroscopy, Oxidation, Injuries, Control systems

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SPIE Journal Paper | 7 October 2020 Open Access

Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism

Daniel Milej, Androu Abdalmalak, Ajay Rajaram, Keith St. Lawrence

NPh, Vol. 7, Issue 04, 045002, (October 2020) https://doi.org/10.1117/12.10.1117/1.NPh.7.4.045002

KEYWORDS: Contamination, Near infrared spectroscopy, Blood circulation, Data modeling, Data acquisition, Brain, Photons, Optical testing, Hemodynamics, Neurophotonics

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Proceedings Article | 11 July 2019 Paper

Assessing extracerebral signal contamination in optical measurements of cerebral blood flow and oxygenation

Daniel Milej, Ajay Rajaram, Androu Abdalmalak, Mahro Khalid, Marwan Shahid, Matthew Kewin, Keith St. Lawrence

Proceedings Volume 11074, 110742J (2019) https://doi.org/10.1117/12.2527150

KEYWORDS: Near infrared spectroscopy, Contamination, Blood circulation, Cerebral blood flow, Tissue optics, Optical testing, Brain, Head, Hemodynamics, Photons

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SPIE Journal Paper | 23 November 2018 Open Access

Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults

Lian He, Wesley B. Baker, Daniel Milej, Venkaiah C. Kavuri, Rickson C. Mesquita, David R. Busch, Kenneth Abramson, Jane Y. Jiang, Mamadou Diop, Keith St. Lawrence, Olivia Amendolia, Francis Quattrone, Ramani Balu, W. Andrew Kofke, Arjun G. Yodh

NPh, Vol. 5, Issue 04, 045006, (November 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.4.045006

KEYWORDS: Calibration, Tissue optics, Tissues, Cerebral blood flow, Brain, Absorption, Head, Blood, Near infrared, Optical properties

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SPIE Journal Paper | 23 December 2017 Open Access

Single-session communication with a locked-in patient by functional near-infrared spectroscopy

Androu Abdalmalak, Daniel Milej, Loretta Norton, Derek Debicki, Teneille Gofton, Mamadou Diop, Adrian Owen, Keith St. Lawrence

NPh, Vol. 4, Issue 04, 040501, (December 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.4.040501

KEYWORDS: Brain, Near infrared spectroscopy, Eye, Neuroimaging, Functional magnetic resonance imaging, Consciousness, Brain-machine interfaces, Monte Carlo methods, Photons, Electroencephalography

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Proceedings Article | 26 April 2016 Presentation

A time-resolved subtraction method for evaluating the optical properties of layered turbid media (Conference Presentation)

Daniel Milej, Androu Abdalmalak, Mamadou Diop, Adam Liebert, Keith St. Lawrence

Proceedings Volume 9706, 970616 (2016) https://doi.org/10.1117/12.2209595

KEYWORDS: Optical properties, Monte Carlo methods, Data modeling, Tissue optics, Medical research, Statistical analysis, Absorption, Scattering, Tissues, Error analysis

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Proceedings Article | 25 March 2016 Paper

Assessing the feasibility of time-resolved fNIRS to detect brain activity during motor imagery

Androu Abdalmalak, Daniel Milej, Mamadou Diop, Lorina Naci, Adrian Owen, Keith St. Lawrence

Proceedings Volume 9690, 969002 (2016) https://doi.org/10.1117/12.2209587

KEYWORDS: Brain, Near infrared spectroscopy, Functional magnetic resonance imaging, Neuroimaging, Brain-machine interfaces, Optical testing, Diffuse reflectance spectroscopy, Biomedical optics, Human-machine interfaces, Picosecond phenomena, Photons, Shape memory alloys, Head, Data acquisition, In vivo imaging

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SPIE Journal Paper | 28 October 2015 Open Access

Optimization of the method for assessment of brain perfusion in humans using contrast-enhanced reflectometry: multidistance time-resolved measurements

Daniel Milej, Dariusz Janusek, Anna Gerega, Stanislaw Wojtkiewicz, Piotr Sawosz, Joanna Treszczanowicz, Wojciech Weigl, Adam Liebert

JBO, Vol. 20, Issue 10, 106013, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106013

KEYWORDS: Targeting Task Performance metric, Brain, Tissue optics, Monte Carlo methods, Photons, Statistical analysis, Absorption, In vivo imaging, Reflectometry, Optical fibers

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SPIE Journal Paper | 14 August 2014 Open Access

Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol

Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Daniel Milej, Norbert Żołek, Michał Kacprzak, Piotr Sawosz, Roman Maniewski, Adam Liebert, Salavat Magazov, Jeremy Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Alessandro Torricelli, Davide Contini, Rebecca Re, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Antonio Pifferi

JBO, Vol. 19, Issue 08, 086012, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086012

KEYWORDS: Absorption, Brain, Neuroimaging, Imaging systems, Optical properties, Sensors, Data analysis, Liquids, Biomedical optics, Spatial resolution

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SPIE Journal Paper | 14 August 2014 Open Access

Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol

Heidrun Wabnitz, Dieter Taubert, Mikhail Mazurenka, Oliver Steinkellner, Alexander Jelzow, Rainer Macdonald, Daniel Milej, Piotr Sawosz, Michał Kacprzak, Adam Liebert, Robert Cooper, Jeremy Hebden, Antonio Pifferi, Andrea Farina, Ilaria Bargigia, Davide Contini, Matteo Caffini, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Alessandro Torricelli

JBO, Vol. 19, Issue 08, 086010, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086010

KEYWORDS: Neuroimaging, Brain, Imaging systems, Sensors, Tissue optics, Biomedical optics, In vivo imaging, Transmittance, Absorption, Solids

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Proceedings Article | 28 February 2013 Paper

Performance assessment of time-domain optical brain imagers: a multi-laboratory study

Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Antonio Pifferi, Alessandro Torricelli, Davide Contini, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Daniel Milej, Norbert Zolek, Michal Kacprzak, Piotr Sawosz, Adam Liebert, Salavat Magazov, Jeremy Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti

Proceedings Volume 8583, 85830L (2013) https://doi.org/10.1117/12.2002438

KEYWORDS: Absorption, Data analysis, Brain, Neuroimaging, Imaging systems, Spatial resolution, Liquids, Optical properties, Sensors, Brain imaging

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SPIE Journal Paper | 2 August 2012 Open Access

Multiwavelength time-resolved detection of fluorescence during the inflow of indocyanine green into the adult's brain

Anna Gerega, Daniel Milej, Marcin Botwicz, Norbert Zolek, Michal Kacprzak, Beata Toczylowska, Roman Maniewski, Adam Liebert, Wojciech Weigl, Ewa Mayzner-Zawadzka, Wojciech Wierzejski

JBO, Vol. 17, Issue 8, 087001, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.087001

KEYWORDS: Luminescence, Signal detection, Fluorescence spectroscopy, Tissues, Absorption, Brain, Head, In vivo imaging, Indocyanine green, Magnesium

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SPIE Journal Paper | 1 June 2011 Open Access

Wavelength-resolved measurements of fluorescence lifetime of indocyanine green

Anna Gerega, Norbert Zolek, Tomasz Soltysinski, Daniel Milej, Piotr Sawosz, Beata Toczylowska, Adam Liebert

JBO, Vol. 16, Issue 06, 067010, (June 2011) https://doi.org/10.1117/12.10.1117/1.3593386

KEYWORDS: Luminescence, Photons, Absorption, Indocyanine green, Tissues, Femtosecond phenomena, Liver, Blood, Signal detection, Single photon detectors

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SPIE Journal Paper | 1 April 2011 Open Access

Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation

Adam Liebert, Piotr Sawosz, Daniel Milej, Michal Kacprzak, Marcin Botwicz, Roman Maniewski, Wojciech Weigl, Ewa Mayzner-Zawadzka, Joanna Maczewska, Katarzyna Fronczewska, Leszek Królicki

JBO, Vol. 16, Issue 04, 046011, (April 2011) https://doi.org/10.1117/12.10.1117/1.3574018

KEYWORDS: Tissues, Brain, Photons, Indocyanine green, Natural surfaces, Near infrared spectroscopy, Diffuse reflectance spectroscopy, In vivo imaging, Tissue optics, Sensors

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