Local optic axis mapping for airway smooth muscle assessment in catheter-based polarization-sensitive optical coherence tomography (Conference Presentation)

Qingyun Li; Karol Karnowski; Peter B. Noble; Michael Hackmann; Onur Çetinkaya; Barry Cense; Alan James; Martin Villiger; David D. Sampson

doi:10.1117/12.2510838

7 March 2019 Local optic axis mapping for airway smooth muscle assessment in catheter-based polarization-sensitive optical coherence tomography (Conference Presentation)

Qingyun Li, Karol Karnowski, Peter B. Noble, Michael Hackmann, Onur Çetinkaya, Barry Cense, Alan James, Martin Villiger, David D. Sampson

Author Affiliations +

Proceedings Volume 10854, Endoscopic Microscopy XIV; 108540U (2019) https://doi.org/10.1117/12.2510838
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Tissue with fibrillar architecture, such as collagen or muscle fiber, exhibits birefringence. In addition to the scalar amount of birefringence, the orientation of the birefringence axis, i.e. the fast optic axis, provides important information on the physical orientation of the fibrillar tissue components. We have previously demonstrated local optic axis mapping using bench-top fiber-based polarization-sensitive optical coherence tomography (PS-OCT), by compensating for the transmission through fiber and system elements, imperfect system alignment, and preceding tissue layers. Using depth-multiplexed PS-OCT, the compensation considers both retardation and diattenuation and is applied in the wavenumber domain, preserving the full axial resolution of the system. Here, we extend our approach to catheter-based imaging. Analyzing a reflection signal from the distal tip of the optical probe, we decompose the recovered system transmission into a static component and a varying catheter transmission to accurately correct for the rotation-dependent transmission through the catheter. Catheter-based local optic axis mapping is validated with a custom-made birefringence phantom. Imaging ex-vivo human bronchus demonstrates the utility of reconstructing the local optic axis orientation to assess airway smooth muscle (ASM), which is oriented approximately orthogonal from the surrounding tissue, offering strong optic axis orientation contrast. Thickening and contraction of the ASM is considered a primary cause of breathing difficulties, and the capacity to clearly image the ASM could lead to an improved understanding of diseases such as asthma.

Conference Presentation

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Qingyun Li, Karol Karnowski, Peter B. Noble, Michael Hackmann, Onur Çetinkaya, Barry Cense, Alan James, Martin Villiger, and David D. Sampson "Local optic axis mapping for airway smooth muscle assessment in catheter-based polarization-sensitive optical coherence tomography (Conference Presentation)", Proc. SPIE 10854, Endoscopic Microscopy XIV, 108540U (7 March 2019); https://doi.org/10.1117/12.2510838

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KEYWORDS

Tissue optics

Optical coherence tomography

Birefringence

Associative arrays

Collagen

Optical alignment

Optical components

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