Volume 12 Issue S1 | Journal of Medical Imaging

Journal of Medical Imaging

VOL. 12 · NO. S1 | January 2025

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Special Issue Celebrating Digital Tomosynthesis: Past, Present, and Future (2)

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Special Issue Celebrating Digital Tomosynthesis: Past, Present, and Future

In-silico study of the impact of system design parameters on microcalcification detection in wide-angle digital breast tomosynthesis

Xiaoyu Duan, Hailiang Huang, Wei Zhao

Journal of Medical Imaging, Vol. 12, Issue S1, S13002, (July 2024) https://doi.org/10.1117/1.JMI.12.S1.S13002

TOPICS: Digital breast tomosynthesis, Signal to noise ratio, Imaging systems, Design, Sensors, Tunable filters, Breast, Quantum noise, Object detection, CMOS sensors

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Purpose

Accurate detection of microcalcifications (μCalcs) is crucial for the early detection of breast cancer. Some clinical studies have indicated that digital breast tomosynthesis (DBT) systems with a wide angular range have inferior μCalc detectability compared with those with a narrow angular range. This study aims to (1) provide guidance for optimizing wide-angle (WA) DBT for improving μCalcs detectability and (2) prioritize key optimization factors.

Approach

An in-silico DBT pipeline was constructed to evaluate μCalc detectability of a WA DBT system under various imaging conditions: focal spot motion (FSM), angular dose distribution (ADS), detector pixel pitch, and detector electronic noise (EN). Images were simulated using a digital anthropomorphic breast phantom inserted with 120 μm μCalc clusters. Evaluation metrics included the signal-to-noise ratio (SNR) of the filtered channel observer and the area under the receiver operator curve (AUC) of multiple-reader multiple-case analysis.

Results

Results showed that FSM degraded μCalcs sharpness and decreased the SNR and AUC by 5.2% and 1.8%, respectively. Non-uniform ADS increased the SNR by 62.8% and the AUC by 10.2% for filtered backprojection reconstruction with a typical clinical filter setting. When EN decreased from 2000 to 200 electrons, the SNR and AUC increased by 21.6% and 5.0%, respectively. Decreasing the detector pixel pitch from 85 to 50 μm improved the SNR and AUC by 55.6% and 7.5%, respectively. The combined improvement of a 50 μm pixel pitch and EN200 was 89.2% in the SNR and 12.8% in the AUC.

Conclusions

Based on the magnitude of impact, the priority for enhancing μCalc detectability in WA DBT is as follows: (1) utilizing detectors with a small pixel pitch and low EN level, (2) allocating a higher dose to central projections, and (3) reducing FSM. The results from this study can potentially provide guidance for DBT system optimization in the future.

Estimation of the absorbed dose in simultaneous digital breast tomosynthesis and mechanical imaging

Anna Bjerkén, Hanna Tomic, Sophia Zackrisson, Magnus Dustler, Predrag Bakic, Anders Tingberg

Journal of Medical Imaging, Vol. 12, Issue S1, S13003, (July 2024) https://doi.org/10.1117/1.JMI.12.S1.S13003

TOPICS: Digital breast tomosynthesis, Breast, Sensors, Polymethylmethacrylate, Mammography, Radiography, Breast cancer, Imaging systems, Medicine, Image sensors

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