Prof. Kevin W. Eliceiri
RRF Walter H. Helmerich Professor Medical Physics at Univ. of Wisconsin-Madison
SPIE Involvement:
Senior Members Committee | Conference Program Committee | Author | Student Chapter Advisor
Profile Summary

Dr. Eliceiri has been conducting research on computational and optical approaches to live cell imaging for two decades, with a focus on multidimensional fluorescence approaches for cell studies and image informatics tools for image analysis. Under his NIH P41 funded “Center for Open Bioimage Analysis” (COBA) his lab develops and maintain the open-source software FIJI and ImageJ while making new deep learning tools and workflow solutions for bioimaging. A major focus of his research is to develop and apply non-invasive optical and computational approaches for understanding the role of the cellular microenvironment in normal and diseased processes. The Eliceiri lab has developed a wide range of second harmonic generation, spectral, lifetime and polarization based imaging methods for investigating cell-cell, cell-matrix and endothelial-stromal interactions and metabolism. Dr. Eliceiri and collaborators demonstrated that alignment of collagen fibers surrounding tumor epithelial cells can serve as a quantitative image-based biomarker for survival of invasive ductal breast carcinoma patients. Specific types of collagen alignment have been identified for their prognostic value in a wide range of cancers and now these tumor associated collagen signatures (TACS) are central to several clinical specimen imaging trials. The Eliceiri lab has also developed specialized open-source tools for collagen quantification that can measure not only the individual collagen fiber geometries like thickness, length, angle, and curvature but also bulk properties like global or local fiber density and alignment. More recently they have been developing automated machine learning approaches to automatically recognize cell-stroma patterns in large histopathology datasets.





Publications (27)

SPIE Journal Paper | 27 September 2024 Open Access
Wihan Adi, Bryan E. Rubio Perez, Yuming Liu, Sydney Runkle, Kevin W. Eliceiri, Filiz Yesilkoy
JBO, Vol. 29, Issue 09, 093511, (September 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.9.093511
KEYWORDS: Collagen, Second harmonic generation, Tissues, Education and training, Mid infrared, Biological samples, Machine learning, Tumors, Hyperspectral imaging, Data modeling

SPIE Journal Paper | 14 June 2024 Open Access
Jason T. Smith, Chao J. Liu, Jeannine Degnan, Jonathan N. Ouellette, Matthew W. Conklin, Anna V. Kellner, Christina M. Scribano, Laura Hrycyniak, Jonathan D. Oliner, Chris Zahm, Eric Wait, Kevin W. Eliceiri, John Rafter
JBO, Vol. 29, Issue S2, S22709, (June 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S2.S22709
KEYWORDS: Cell death, Tumors, Fluorescence lifetime imaging, Tissues, Cancer, Chemotherapy, Fluorescence, Tumor growth modeling, Autofluorescence, Photons

Proceedings Article | 3 October 2023 Presentation + Paper
Proceedings Volume 12654, 1265404 (2023) https://doi.org/10.1117/12.2676281
KEYWORDS: Hyperspectral imaging, Plasmonics, Brain tissue, Tissues, Quantum plasmonics, Polarization, Infrared spectroscopy, Imaging spectroscopy, Polymethylmethacrylate, Phosphates, Magnetism

SPIE Journal Paper | 21 June 2023 Open Access
JBO, Vol. 28, Issue 06, 066502, (June 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.6.066502
KEYWORDS: Single photon avalanche diodes, Fluorescence lifetime imaging, Imaging systems, Cameras, Autofluorescence, Fluorescence, Laser scanners, Biomedical optics, Microscopes, Fluorescence intensity

Proceedings Article | 15 March 2023 Presentation
Proceedings Volume PC12386, PC1238605 (2023) https://doi.org/10.1117/12.2650245
KEYWORDS: Sensors, Microscopy, Fluorescence lifetime imaging, Detector arrays, Cameras, Objectives, Luminescence, Switching, Pulsed laser operation, Photons

Showing 5 of 27 publications
Conference Committee Involvement (26)
Multiphoton Microscopy in the Biomedical Sciences XXV
26 January 2025 | San Francisco, California, United States
Multiscale Imaging and Spectroscopy VI
25 January 2025 | San Francisco, California, United States
Multiphoton Microscopy in the Biomedical Sciences XXIV
28 January 2024 | San Francisco, California, United States
Multiscale Imaging and Spectroscopy V
27 January 2024 | San Francisco, California, United States
Multiphoton Microscopy in the Biomedical Sciences XXIII
29 January 2023 | San Francisco, California, United States
Showing 5 of 26 Conference Committees
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